The emerging role of the mitochondrial-derived peptide humanin in stress resistance.
The emerging role of the mitochondrial-derived peptide humanin in stress resistance.
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DOI：
10.1530/jme-12-0203
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发表时间：
2013-02
影响因子：
3.5
通讯作者：
Cohen P
中科院分区：
文献类型：
--
作者：
Yen K;Lee C;Mehta H;Cohen P
护脑素（一种新型线粒体衍生肽）的发现创造了一种潜在的新类别的生物活性肽。随着越来越多的研究揭示了护脑素的内源性作用及其潜在的药理学用途，其在抗应激方面的作用变得更加清晰。护脑素在体外可保护细胞免受氧化应激、血清饥饿、缺氧和其他损伤，在体内还可改善心血管疾病和阿尔茨海默病。在这篇综述中，我们讨论了护脑素在抗压方面的新作用及其拟议的作用机制。
The discovery of humanin, a novel, mitochondrial-derived peptide, has created a potentially new category of biologically active peptide. As more research unravels the endogenous role of humanin as well as its potential pharmacological use, its role in stress resistance has become clearer. Humanin protects cells from oxidative stress, serum starvation, hypoxia, and other insults in vitro and also improves cardiovascular disease as well as Alzheimer's disease in vivo. In this review, we discuss the emerging role of humanin in stress resistance and its proposed mechanism of action.