TIME COURSE OF URINARY EXCRETION OF INORGANIC PHOSPHATE BY RATS AFTER PARATHYROIDECTOMY AND AFTER INJECTION OF PARATHYROID EXTRACT
TIME COURSE OF URINARY EXCRETION OF INORGANIC PHOSPHATE BY RATS AFTER PARATHYROIDECTOMY AND AFTER INJECTION OF PARATHYROID EXTRACT
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DOI：
10.1210/endo-66-4-610
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发表时间：
1960-01-01
期刊：
影响因子：
4.8
通讯作者：
MUNSON, PL
中科院分区：
文献类型：
--
作者：
BEUTNER, EH;MUNSON, PL
在连续静脉输注生理盐溶液期间，每隔 5 至 15 分钟从代谢限制笼中的未麻醉雄性大鼠中收集自发排泄的尿液，并分析无机磷酸盐 (Pi)。 Pi的排泄率在甲状旁腺切除术后25至52分钟内下降，并在接下来的3至5小时内继续下降。在此间隔结束时，静脉注射甲状旁腺提取物，在 8 分钟内导致尿 Pi 升高。注射后18至48分钟，该速率继续增加至最大值，该值在术前值的范围内。在接下来的一到一个半小时内，速率逐渐下降至注射前的水平。这项工作得出以下结论：甲状旁腺激素在循环中的寿命很短；在正常的完整大鼠中，该激素持续分泌；该激素直接作用于肾小管，影响 Pi 的排泄。讨论了数据对甲状旁腺激素作用模式概念的影响。
Spontaneously voided urine was collected at intervals of 5 to 15 minutes from unanesthetized male rats in metabolic restraining cages during continuous intravenous infusion of physiological salt solution and analyzed for inorganic phosphate (Pi). The rate of excretion of Pi fell within 25 to 52 minutes after parathyroidectomy and continued to decline during the next 3 to 5 hours. At the end of this interval the intravenous injection of parathyroid extract resulted, within 8 minutes, in a rise in urinary Pi. The rate continued to increase to a maximum, 18 to 48 minutes after the injection, which was within the range of the preoperative values. The rate fell gradually toward the pre-injection level during the next one to one and a half hours. The work led to the following conclusions: the life of parathyroid hormone in the circulation is short; in the normal intact rat there is a continuous secretion of the hormone; the hormone acts directly on the renal tubule to influence the excretion of Pi. The bearing of the data on concepts of the mode of action of parathyroid hormone is discussed.