Anti-human immunodeficiency virus drugs are ineffective against Pneumocystis carinii in vitro and in vivo.
Anti-human immunodeficiency virus drugs are ineffective against Pneumocystis carinii in vitro and in vivo.
复制标题
抗人类免疫缺陷病毒药物在体外和体内对卡氏肺孢子虫均无效。
DOI：
10.1086/323991
复制
发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Cushion,MT
中科院分区：
文献类型：
--
作者：
Walzer,PD;Ashbaugh,A;Collins,M;Cushion,MT
人类免疫缺陷病毒（HIV）蛋白酶抑制剂（pi）最近被报道对卡氏肺囊虫细胞培养有活性。分析了12种抗hiv药物对大鼠p的作用。通过ATP细胞毒性试验。茚地那韦和沙奎那韦有轻微的抗p作用。浓度高于临床血清中可达到的水平时的免疫活性；其他pi和核苷和非核苷逆转录酶抑制剂对该生物无活性。抗艾滋病毒药物，单独或联合，并没有实质性地减少细菌计数在治疗的p。免疫抑制小鼠的卡氏肺炎。因此，抗hiv药物对stp几乎没有活性。在这些体外和体内系统中。在解释p易感性报告时应谨慎。cariniito抗hiv药物只能在体外测试的基础上进行
Human immunodeficiency virus (HIV) protease inhibitors (PIs) recently have been reported to be active againstPneumocystis cariniiin cell culture. Twelve anti-HIV drugs were analyzed for their effects against ratP. cariniiby an ATP cytotoxicity assay. Indinavir and saquinavir exhibited slight anti–P. cariniiactivity at concentrations above those that can be clinically achieved in serum; other PIs and nucleoside and nonnucleoside reverse-transcriptase inhibitors were inactive against the organism. Anti-HIV drugs, alone or in combination, did not materially reduce the organism count in the treatment ofP. cariniipneumonia in immunosuppressed mice. Thus, anti-HIV drugs have little or no activity againstP. cariniiin these in vitro and in vivo systems. Caution should be used when interpreting reports of the susceptibility ofP. cariniito anti-HIV drugs on the basis of in vitro testing only