New superselective intra-arterial infusion via superficial temporal artery for cancer of the tongue and tumour tissue platinum concentration after carboplatin (CBDCA) infusion
New superselective intra-arterial infusion via superficial temporal artery for cancer of the tongue and tumour tissue platinum concentration after carboplatin (CBDCA) infusion
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DOI：
10.1016/s1368-8375(98)00018-9
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发表时间：
1998-09-01
期刊：
影响因子：
4.8
通讯作者：
Ueda, M
中科院分区：
文献类型：
--
作者：
Tohnai, I;Fuwa, N;Ueda, M
我们开发了一种新的技术，超选择性动脉化疗舌癌使用修改后的（1.35毫米）血管造影导管。通过新技术证实导管插入舌动脉。我们测量了12例舌癌患者在肿瘤切除前30分钟输注20 mg/m2卡铂（CBDCA）30分钟后切除肿瘤组织中的铂浓度（6例患者：超选择动脉内输注; 6例患者：常规动脉内输注）。肿瘤组织中的平均铂浓度为10.5 +/- 1.2 μ g/g湿重，比常规动脉内输注方法的4.3 +/- 3.8 μ g/g湿重高两倍以上，且有显著差异。这种新的超选择性动脉内输注方法允许将抗癌剂直接输注到供应肿瘤的动脉中，并有望成为舌癌的新治疗方式。(C)1998爱思唯尔科技有限公司版权所有。
We developed a new technique of superselective intra-arterial chemotherapy for tongue cancer using a modified (1.35 mm) angiographic catheter. The catheter was confirmed to be inserted into the lingual artery by the new technique. We measured the platinum concentrations in resected tumour tissues after infusion of carboplatin (CBDCA) at 20 mg/m(2) over 30 min from 30 min before tumour resection in 12 patients with cancer of the tongue (6 patients: superselective intra-arterial infusion; 6 patients: conventional intra-arterial infusion). The mean platinum concentration in tumour tissue was 10.5 +/- 1.2 mu g/g wet, which was more than twice higher than, and significantly different from, 4.3 +/- 3.8 mu g/g wet by the conventional intra-arterial infusion method. This new superselective intra-arterial infusion method allows direct infusion of the anticancer agent into the artery supplying the tumour and is expected to become a new therapeutic modality for cancer of the tongue. (C) 1998 Elsevier Science Ltd. All rights reserved.