Cerebrospinal fluid glutamine as a measure of hepatic encephalopathy.
Cerebrospinal fluid glutamine as a measure of hepatic encephalopathy.
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脑脊液谷氨酰胺作为肝性脑病的衡量标准。
DOI：
10.1001/archinte.1971.00310180049005
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发表时间：
1971
影响因子：
--
通讯作者：
T. Reynolds
中科院分区：
文献类型：
--
作者：
B. T. Hourani;E. Hamlin;T. Reynolds
为探讨脑脊液谷氨酰胺水平与肝性脑病的相关性，对86例肝性脑病患者进行了脑脊液谷氨酰胺水平测定。在51例无肝病患者中，平均CSF谷氨酰胺水平为12.6 ± 5.1 mg/100 ml。在9例肝病但无临床脑病的患者中，平均值为21.6 ± 6.2 mg/100 ml，在26例不同程度的昏迷前和昏迷患者中，平均值为40.3 ± 14 mg/100 ml。脑病的严重程度与谷氨酰胺水平之间存在一定的相关性。脑脊液谷氨酰胺试验是一种容易进行的生化评价，似乎有助于肝性脑病的诊断和评估其严重程度。
To test the correlation between cerebrospinal fluid (CSF) glutamine level and hepatic encephalopathy, measurements were made in 86 patients. In 51 without liver disease, mean CSF glutamine level was 12.6 ± 5.1 mg/100 ml. In nine patients with liver disease but without clinical encephalopathy, the mean value was 21.6 ± 6.2 mg/100 ml and in 26 patients with varying degrees of precoma and coma it was 40.3 ± 14 mg/100 ml. There was a fair correlation between the severity of encephalopathy and the glutamine level. The CSF glutamine test, an easily performed biochemical evaluation, seems useful in the diagnosis of hepatic encephalopathy and in the assessment of its severity.