Incorporating cross-modal statistics in the development and maintenance of multisensory integration.
Incorporating cross-modal statistics in the development and maintenance of multisensory integration.
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DOI：
10.1523/jneurosci.4304-11.2012
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发表时间：
2012-02-15
期刊：
影响因子：
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通讯作者：
Stein BE
中科院分区：
文献类型：
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作者：
Xu J;Yu L;Rowland BA;Stanford TR;Stein BE
本文观察了早期(出生后30-8个月)视-听体验受限的猫上丘(SC)神经元多感觉统合能力的发展。动物被周期性地暴露在视觉和听觉刺激中，这些刺激要么在空间和时间上随机出现，要么总是在时空上协调一致。在其他时候，动物都被关在黑暗中。生理测试大约在2岁时开始。事实证明，暴露于随机的视觉和听觉刺激不足以刺激整合跨模式刺激的能力成熟，但暴露于时空一致的跨模式刺激是非常有效的。后一组神经元的多感觉整合能力与正常动物相似，并在没有后续视觉-听觉体验的情况下保持了16个月以上。此外，神经元能够整合具有与暴露组显著不同的物理特性的刺激。这些观察表明，获得多感觉整合的基础只需要接触到跨通道事件的特定通道组件之间的一致关系，并且对此类事件的持续经验不是维持这些事件所必需的。显然，生命早期跨通道体验的统计数据定义了空间和时间过滤器，这些过滤器决定了跨通道刺激的成分是被整合还是被视为独立的事件，这是一个关键的发展过程，决定了跨通道刺激整合的空间和时间规则，以增强感觉突显和诱发SC介导的运动反应的可能性。
Development of multisensory integration capabilities in superior colliculus (SC) neurons was examined in cats whose visual-auditory experience was restricted to a circumscribed period during early life (postnatal day 30-8 mos). Animals were periodically exposed to visual and auditory stimuli appearing either randomly in space and time, or always in spatiotemporal concordance. At all other times animals were maintained in darkness. Physiological testing was initiated at approximately 2 years of age. Exposure to random visual and auditory stimuli proved insufficient to spur maturation of the ability to integrate cross-modal stimuli, but exposure to spatiotemporally concordant cross-modal stimuli was highly effective. The multisensory integration capabilities of neurons in the latter group resembled those of normal animals and were retained for more than 16 months in the absence of subsequent visual-auditory experience. Furthermore, the neurons were capable of integrating stimuli having physical properties differing significantly from those in the exposure set. These observations suggest that acquiring the rudiments of multisensory integration requires little more than exposure to consistent relationships between the modality-specific components of a cross-modal event, and that continued experience with such events is not necessary for their maintenance. Apparently, the statistics of cross-modal experience early in life define the spatial and temporal filters that determine if the components of cross-modal stimuli are to be integrated or treated as independent events, a crucial developmental process that determines the spatial and temporal rules by which cross-modal stimuli are integrated to enhance both sensory salience and the likelihood of eliciting an SC-mediated motor response.