Overview of chemical sampling techniques.
Overview of chemical sampling techniques.
复制标题
化学采样技术概述。
DOI：
10.1016/0165-0270(93)90091-5
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发表时间：
1993
影响因子：
3
通讯作者：
Paredes,W
中科院分区：
文献类型：
--
作者：
Gardner,EL;Chen,J;Paredes,W
尽管许多对大脑化学微环境进行采样的想法在三十年前或更早的时候就已经存在，至少是处于萌芽状态，但过去十年见证了特别惊人的发展、完善和使用激增。我们现在能够以值得称赞的灵敏度、选择性和速度水平测量体内几乎任何内源性脑化学物质。能够将神经化学事件与持续行为和/或显着环境线索和刺激的呈现相关联的长期梦想目标已经基本实现。对现有技术的进一步改进很可能会达到几年前难以想象的分析水平。对理论构建和假设检验的影响是巨大的，特别是在行为神经科学和生物精神病学等基本未开发的领域。这是真正令人兴奋的时刻。
Although many of the ideas for sampling the chemical microenvironment of the brain were present, at least in nascent form, three decades ago or more, the last 10 years have witnessed a particularly spectacular surge of development, refinement, and use. We are now able to measure virtually any endogenous brain chemical in vivo at commendable levels of sensitivity, selectivity, and speed. The long-dreamt-of goal of being able to correlate neurochemical events with ongoing behavior and/or presentation of salient environmental cues and stimuli has already been largely achieved. Further refinements of existing techniques may well lead to levels of analysis inconceivable even a few years ago. The implications for theory-building and hypothesis-testing are enormous, particularly within such essentially virgin domains as behavioral neuroscience and biological psychiatry. These are truly exciting times.