Pd-Catalyzed Asymmetric Allylic Substitution Cascade of Substituted 4-Hydroxy-2H-pyrones with meso-Allyl Dicarbonates.
Pd-Catalyzed Asymmetric Allylic Substitution Cascade of Substituted 4-Hydroxy-2H-pyrones with meso-Allyl Dicarbonates.
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DOI：
10.1021/acs.orglett.2c00937
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发表时间：
2022-05
期刊：
影响因子：
5.2
通讯作者：
Ya‐nan Zheng;Siqi Dong;Kai Xu;Delong Liu;Wanbin Zhang
中科院分区：
文献类型：
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作者：
Ya‐nan Zheng;Siqi Dong;Kai Xu;Delong Liu;Wanbin Zhang
An efficient Pd-catalyzed asymmetric allylic substitution cascade of 4-hydroxy-2H-pyrones with meso-allyl dicarbonates has been developed for the synthesis of kinetic chiral tetrahydro-1H-pyrano[4,3-b]benzofuran-1-one products in ≤87% yield and ≤99% ee. The protocol was achieved via a temperature-controlled kinetic control process, which has been illustrated by means of the experimental results and control experiments. The reaction could be conducted on a gram scale, and the resulting product allows for several transformations.
