Expression of the hyaluronan receptor LYVE-1 is not restricted to the lymphatic vasculature; LYVE-1 is also expressed on embryonic blood vessels
Expression of the hyaluronan receptor LYVE-1 is not restricted to the lymphatic vasculature; LYVE-1 is also expressed on embryonic blood vessels
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DOI：
10.1002/dvdy.21605
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发表时间：
2008-07-01
影响因子：
2.5
通讯作者：
Harvey, Natasha L.
中科院分区：
文献类型：
--
作者：
Gordon, Emma J.;Gale, Nicholas W.;Harvey, Natasha L.
透明质酸受体Lyve-1的表达是为数不多的用于区分淋巴管和血管的标准之一。到目前为止，据报道，内皮细胞Lyve-1的表达仅限于淋巴管以及淋巴、肝和脾窦。在这里，我们提供了LYVE-1在小鼠胚胎发育过程中在卵黄囊血管上表达的第一个证据。LYVE-1在E9.5的卵黄囊毛细血管丛中普遍表达，然后在血管重构过程中逐渐下调动脉内皮细胞的表达。LYVE-1也在胚胎早期的胚胎内动、静脉内皮细胞以及肺和心内膜的内皮细胞上表达。在整个胚胎发育过程中。这些发现对于在胚胎发育和新生淋巴管生成过程中使用LYVE-1作为淋巴管系统的特异性标记物具有重要意义。据我们所知，我们的数据也是第一次证明小鼠卵黄囊中没有淋巴管。
Expression of the hyaluronan receptor LYVE-1 is one of few available criteria used to discriminate lymphatic vessels from blood vessels. Until now, endothelial LYVE-1 expression was reported to be restricted to lymphatic vessels and to lymph node, liver, and spleen sinuses. Here, we provide the first evidence that LYVE-1 is expressed on blood vessels of the yolk sac during mouse embryogenesis. LYVE-1 is ubiquitously expressed in the yolk sac capillary plexus at E9.5, then becomes progressively down-regulated on arterial endothelium during vascular remodelling. LYVE-1 is also expressed on intra-embryonic arterial and venous endothelium at early embryonic stages and on endothelial cells of the lung and endocardium. throughout embryogenesis. These findings have important implications for the use of LYVE-1 as a specific marker of the lymphatic vasculature during embryogenesis and neo-lymphangiogenesis. Our data are also the first demonstration, to our knowledge, that the mouse yolk sac is devoid of lymphatic vessels.