The Role of Tumor-Infiltrating B Cells in Tumor Immunity
The Role of Tumor-Infiltrating B Cells in Tumor Immunity
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DOI：
10.1155/2019/2592419
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发表时间：
2019-09-24
影响因子：
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通讯作者：
Cui, Jiu Wei
中科院分区：
文献类型：
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作者：
Guo, Fei Fei;Cui, Jiu Wei
阐明淋巴细胞在肿瘤免疫中的作用的早期研究主要集中在T细胞上。然而，B细胞在肿瘤免疫中的作用在最近的研究中越来越受到更好的关注。浸润肿瘤组织的B细胞称为肿瘤浸润性B细胞（TIB）。研究发现，TIB在调节肿瘤免疫中发挥多方面的双重作用，而不仅仅是抑制或促进肿瘤。本文综述了TIBs与肿瘤复杂性关系的最新研究进展，并对TIBs作为肿瘤生物标志物和潜在的治疗靶点提出了新的思路。
Earlier studies on elucidating the role of lymphocytes in tumor immunity predominantly focused on T cells. However, the role of B cells in tumor immunity has increasingly received better attention in recent studies. The B cells that infiltrate tumor tissues are called tumor-infiltrating B cells (TIBs). It is found that TIBs play a multifaceted dual role in regulating tumor immunity rather than just tumor inhibition or promotion. In this article, latest research advances focusing on the relationship between TIBs and tumor complexity are reviewed, and light is shed on some novel ideas for exploiting TIBs as a possible tumor biomarker and potential therapeutic target against tumors.