DRUG KINETICS AND DRUG-RESISTANCE IN OPTIMAL CHEMOTHERAPY
DRUG KINETICS AND DRUG-RESISTANCE IN OPTIMAL CHEMOTHERAPY
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DOI：
10.1016/0025-5564(94)00027-w
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发表时间：
1995-02-01
影响因子：
4.3
通讯作者：
BASSANEZI, RC
中科院分区：
文献类型：
--
作者：
COSTA, MIS;BOLDRINI, JL;BASSANEZI, RC
本文提出了一个周期非特异性化疗中控制肿瘤细胞生长的微分方程组。一类最优控制问题考虑了一阶药物动力学和药物抗性。结果表明，对应于药物注射的最大速率的策略对于细胞生长的马尔萨斯模型是最优的（这是肿瘤生长的初始阶段的相对较好的模型）。对于更一般的细胞生长模型，这种策略在某些条件下被证明是次优的。
A system of differential equations for the control of tumor cells growth in a cycle nonspecific chemotherapy is presented. First-order drug kinetics and drug resistance are taken into account in a class of optimal control problems. The results show that the strategy corresponding to the maximum rate of drug injection is optimal for the Malthusian model of cell growth (which is a relatively good model for the initial phase of tumor growth). For more general models of cell growth this strategy proved to be suboptimal under certain conditions.