Associations of Temporal Cardiometabolic Patterns and Incident SARS-CoV-2 Infection Among U.S. Blood Donors With Serologic Evidence of Vaccination.
Associations of Temporal Cardiometabolic Patterns and Incident SARS-CoV-2 Infection Among U.S. Blood Donors With Serologic Evidence of Vaccination.
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DOI：
10.1016/j.focus.2024.100186
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发表时间：
2024-04
期刊：
影响因子：
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通讯作者：
Custer, Brian
中科院分区：
文献类型：
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作者：
Yu, Elaine A;Stone, Mars;Bravo, Marjorie D;Grebe, Eduard;Bruhn, Roberta L;Lanteri, Marion C;Townsend, Mary;Kamel, Hany;Jones, Jefferson M;Busch, Michael P;Custer, Brian
心脏代谢对疫苗接种后 SARS-CoV-2 感染风险的影响尚不清楚。间歇性高血压与疫苗接种后感染风险相关。心脏代谢模式和疫苗接种后感染的关联因性别而异。心脏代谢疾病与 COVID-19 的严重程度相关；然而，心脏代谢健康对接种疫苗后 SARS-CoV-2 感染的影响仍不清楚。我们的目的是调查具有疫苗接种血清学证据的人群中颞叶血压和总胆固醇模式与 SARS-CoV-2 感染事件之间的关联。在这一前瞻性献血者队列中，我们于 2020 年至 2021 年收集了血液样本，并检测了 SARS-CoV-2 核衣壳蛋白抗体血清阳性的结合抗体。我们在整个研究时间点将参与者分为血压和总胆固醇的个体模式亚组（持续、间歇或不升高[收缩压<130 mmHg，舒张压<80 mmHg，总胆固醇<200 mg/dL]）。在 13,930 名捐赠者共 39,736 次捐赠（相当于 1,127,071 人日）中，有 221 例有疫苗接种血清学证据的人感染 SARS-CoV-2（1.6%）。根据多变量泊松回归，与血压正常的参与者相比，具有疫苗接种风险血清学证据的参与者（调整后的发病率=2.07；95% CI=1.44、2.96；p<0.01）中，间歇性高血压与更多的 SARS-CoV-2 感染相关。在男性中，间歇性升高的总胆固醇（调整后的发病率比=1.90；95% CI=1.32, 2.74；p<0.01）和基线时较高的BMI（调整后的风险比=1.44；95% CI=1.07, 1.93；p=0.01；每10个单位）与有疫苗接种可能性的血清学证据的人群中更大的SARS-CoV-2感染相关；这些关联在女性中无效（均 p>0.05）。我们的研究结果强调，心脏代谢健康（尤其是血压）的益处包括接种疫苗后感染 SARS-CoV-2 的风险较低。
Cardiometabolic impacts on postvaccination SARS-CoV-2 infection risk are unclear. Intermittent hypertension was associated with postvaccination infection risk. Cardiometabolic pattern and postvaccination infection associations differed by gender. Cardiometabolic diseases are associated with greater COVID-19 severity; however, the influences of cardiometabolic health on SARS-CoV-2 infections after vaccination remain unclear. Our objective was to investigate the associations between temporal blood pressure and total cholesterol patterns and incident SARS-CoV-2 infections among those with serologic evidence of vaccination. In this prospective cohort of blood donors, blood samples were collected in 2020–2021 and assayed for binding antibodies of SARS-CoV-2 nucleocapsid protein antibody seropositivity. We categorized participants into intraindividual pattern subgroups of blood pressure and total cholesterol (persistently, intermittently, or not elevated [systolic blood pressure <130 mmHg, diastolic blood pressure <80 mmHg, total cholesterol <200 mg/dL]) across the study time points. Among 13,930 donors with 39,736 donations representing 1,127,071 person-days, there were 221 incident SARS-CoV-2 infections among those with serologic evidence of vaccination (1.6%). Intermittent hypertension was associated with greater SARS-CoV-2 infections among those with serologic evidence of vaccination risk (adjusted incidence rate ratio=2.07; 95% CI=1.44, 2.96; p<0.01) than among participants with consistent normotension on the basis of a multivariable Poisson regression. Among men, intermittently elevated total cholesterol (adjusted incidence rate ratio=1.90; 95% CI=1.32, 2.74; p<0.01) and higher BMI at baseline (adjusted hazard ratio=1.44; 95% CI=1.07, 1.93; p=0.01; per 10 units) were associated with greater SARS-CoV-2 infections among those with serologic evidence of vaccination probability; these associations were null among women (both p>0.05). Our findings underscore that the benefits of cardiometabolic health, particularly blood pressure, include a lower risk of SARS-CoV-2 infection after vaccination.