CA-125 level as a prognostic indicator in type I and type II epithelial ovarian cancer.
CA-125 level as a prognostic indicator in type I and type II epithelial ovarian cancer.
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DOI：
10.1097/igc.0b013e31828f7a24
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发表时间：
2013-06
期刊：
影响因子：
--
通讯作者：
Liu J
中科院分区：
文献类型：
--
作者：
Chen X;Zhang J;Cheng W;Chang DY;Huang J;Wang X;Jia L;Rosen DG;Zhang W;Yang D;Gershenson DM;Sood AK;Bast RC Jr;Liu J
大多数上皮性卵巢癌患者在CA-125正常的情况下达到完全临床缓解，但仍会复发并死于疾病。本研究旨在确定CA-125水平是否在初级治疗之前，期间和之后提供I型和II型卵巢癌的预后信息。在这项回顾性研究中，我们确定了1984年至2011年间达到CCR的410例上皮性卵巢癌患者。采用考克斯比例风险模型和对数秩检验评估CA-125最低值、组织型和预后之间的关系。II型卵巢癌患者的基线血清CA-125浓度高于I型卵巢癌患者（p < 0.001）。CA-125最低值是PFS（p < 0.001）和OS（p = 0.035）持续时间的独立预测因子。CA-125 ≤ 10 U/ml患者的PFS和OS持续时间分别为21.7和79.4个月，11-35 U/ml患者的PFS和OS持续时间分别为13.6和64.6个月（分别为p = 0.01和0.002）。组织型是PFS的独立预测因子（p = 0.041）：I型患者的PFS和OS持续时间长于II型患者（分别为p < 0.001和< 0.001）。最低CA-125和组织型可预测经历CCR的卵巢癌的PFS和OS持续时间。CA-125水平为11-35 U/ml和II型疾病患者的PFS和OS持续时间短于CA-125水平≤ 10 U/ml和I型患者。
The majority of patients with epithelial ovarian cancer achieved a complete clinical remission with normal CA-125 will still relapse and die from their disease. The present study was to determine whether CA-125 levels before, during and after primary treatment provided prognostic information for both Type I and Type II ovarian cancer. In this retrospective study, we identified 410 epithelial ovarian cancer patients who had achieved a CCR between 1984 and 2011. A Cox proportional hazards model and log-rank test were used to assess associations between the nadir CA-125, histotype, and prognosis. The baseline serum CA-125 concentration was higher in patients with type II ovarian cancer than in those with type I (p < 0.001). The nadir CA-125 was an independent predictor of PFS (p < 0.001) and OS (p = 0.035) duration. The PFS and OS durations were 21.7 and 79.4 months in patients with CA-125 ≤ 10 U/ml and 13.6 and 64.6 months in those with 11-35 U/ml (p = 0.01 and 0.002, respectively). Histotype was an independent predictor of PFS (p = 0.041): the PFS and OS durations of type I patients were longer than those in type II (p < 0.001 and < 0.001, respectively). The nadir CA-125 and the histotype are predictive of PFS and OS duration in ovarian cancers experienced a CCR. PFS and OS durations were shorter in patients with CA-125 levels of 11-35 U/ml and type II disease than in those with ≤ 10 U/ml and type I.
影响因子：
3.9
作者：
Kang S;Kim TJ;Seo SS;Kim BG;Bae DS;Park SY
通讯作者：
Park SY