Progesterone withdrawal effects 'in the open field test can be predicted by elevated plus maze performance
Progesterone withdrawal effects 'in the open field test can be predicted by elevated plus maze performance
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DOI：
10.1016/j.yhbeh.2006.03.002
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发表时间：
2006-08-01
影响因子：
3.5
通讯作者：
Backstrom, Torbjorn
中科院分区：
文献类型：
--
作者：
Lofgren, Magnus;Johansson, Inga-Maj;Backstrom, Torbjorn
别孕烯醇酮（3 α-羟基-5 α-甾烷-20-酮）是孕酮的环A还原代谢物，其在月经周期的黄体期、怀孕期间和压力事件中自然产生。类固醇激素通过增加GABA（A）受体的氯离子流量来抑制神经功能。其作用和随后的戒断症状与酒精、苯二氮卓类药物和巴比妥类药物引起的症状相似。本研究考察了孕酮的戒断效应与个体基线探索和冒险行为的影响。在激素治疗前，在高架十字迷宫（高架十字迷宫）上对大鼠进行测试，以评估冒险和探索开放区域和高架区域的差异。治疗包括连续10次每日一次孕酮或载体s.c.注射剂在治疗的最后一天，除了黄体酮外，还注射雌二醇，然后在旷场试验（OF）中测试之前停药24小时。孕酮治疗的大鼠在OF中表现出开放区回避的戒断效应。溶剂处理的对照大鼠显示出在WAR和OF参数之间的强相关性。孕酮组在停药时未发现这种关系。大鼠开放臂入口的数量更大，在预试验中表现出增加的敏感性孕酮戒断（PWD）相比，大鼠低探索和冒险。结果表明，PWD的影响与个人的探索和冒险有关。此外，PWD和PMS/PMDD在有关个人特质的可能的类比进行了讨论。(c)2006年爱思唯尔公司All rights reserved.
Allopregnanolone (3alpha-hydroxy-5alpha-pregnane-20-one) is a ring-A-reduced metabolite of progesterone, which is naturally produced during the luteal phase of the menstrual cycle, during pregnancy and by stressful events. The steroid hormone inhibits neural functions through increased chloride ion flux through the GABA(A) receptor. The effects and subsequent withdrawal symptoms are similar to those caused by alcohol, benzodiazepines and barbiturates. This study examined the withdrawal effects of progesterone with regards to the influence of individual baseline exploration and risk taking. Rats were tested on the elevated plus maze (EPM) before hormonal treatment, in order to evaluate differences in risk taking and exploration of open and elevated areas. Treatment consisted of ten consecutive once a day progesterone or vehicle s.c. injections. On the last day of treatment, estradiol was injected in addition to progesterone, followed by a 24-h withdrawal before testing in the open field test (OF). Progesterone-treated rats showed a withdrawal effect of open area avoidance in the OF. The vehicle-treated control rats showed strong correlations between the EPM and OF parameters. This relationship was not found for the progesterone group at withdrawal. Rats with greater numbers of open arm entrance in the EPM pretest showed an increased sensitivity to progesterone withdrawal (PWD) compared to rats with low exploration and risk taking. The results indicate that the effects of PWD relate to individual exploration and risk taking. Furthermore, the possible analogy of PWD and PMS/PMDD in relation to individual traits is discussed. (c) 2006 Elsevier Inc. All rights reserved.