Cortical gray matter deficit in patients with bipolar disorder
Cortical gray matter deficit in patients with bipolar disorder
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DOI：
10.1016/s0920-9964(99)00063-8
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发表时间：
1999-12-21
影响因子：
4.5
通讯作者：
Pfefferbaum, A
中科院分区：
文献类型：
--
作者：
Lim, KO;Rosenbloom, MJ;Pfefferbaum, A
背景资料：精神分裂症患者的皮质灰质体积缺损和脑室扩大已得到充分证实，但双相情感障碍患者的皮质灰质体积缺损和脑室扩大尚未得到充分证实。整体皮质灰质、白色物质和脑沟CSF，以及侧脑室和第三脑室容积测量值，来自年龄匹配的双极（n = 9），精神分裂症（n = 9），对照组（n = 16）。所有受试者均无酒精或其他物质dependence.Results的历史：相对于对照组，双相情感障碍患者有广泛的皮质灰质，但不是皮质白色物质的体积赤字。精神分裂症患者有一个更严重的皮质灰质赤字和更大的脑沟和侧脑室扩大比bipolar patients.Conclusions：这组双相情感障碍患者有一个广泛的皮质灰质赤字类似，但不太明显，观察到精神分裂症患者。(C)1999 Elsevier Science B.V.保留所有权利。
Background: cortical gray matter volume deficit and ventricular enlargement are well documented in schizophrenia, but their presence in bipolar disorder is less well established.Methods: global cortical gray matter, white matter and sulcal CSF, as well as lateral and third ventricular volume measures, were derived from axial MRI brain images obtained on age-matched bipolar (n = 9), schizophrenic (n = 9), and control (n = 16) subjects. All subjects were free of history of alcohol or other substance dependence.Results: relative to controls, bipolar patients had widespread volume deficits of cortical gray matter but not of cortical white matter. Schizophrenic patients had an even more severe cortical gray matter deficit and greater sulcal and lateral ventricular enlargement than the bipolar patients.Conclusions: this group of patients with bipolar disorder had a widespread deficit of cortical gray matter similar to, but less pronounced than, that observed in patients with schizophrenia. (C) 1999 Elsevier Science B.V. All rights reserved.