Effect of lifestyle intervention in patients with type 2 diabetes: A meta-analysis
Effect of lifestyle intervention in patients with type 2 diabetes: A meta-analysis
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DOI：
10.1016/j.metabol.2014.10.018
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发表时间：
2015-02-01
影响因子：
9.8
通讯作者：
Yang, Hua-Zhang
中科院分区：
文献类型：
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作者：
Chen, Liang;Pei, Jian-Hao;Yang, Hua-Zhang
Objective.生活方式干预对2型糖尿病患者临床危险因素的影响尚不清楚。本荟萃分析的目的是评估综合生活方式改变（如饮食、运动和教育）对2型糖尿病患者心血管疾病危险因素临床标志物的影响。我们检索了Medline、科克伦、EMBASE和Google Scholar（截至2013年8月31日）中比较标准治疗（对照组）与包括生活方式改变的治疗方案（干预组）的随机对照试验。主要结果是降低心血管疾病的危险因素，包括体重指数（BMI）、糖化血红蛋白（HbA 1c）、收缩压（SBP）、舒张压（DBP）、高密度脂蛋白胆固醇（HDL-c）和低密度脂蛋白胆固醇（LDL-c）。共有16项研究被纳入荟萃分析。与对照组相比，BMI较基线变化平均值的标准化差异显着有利于干预（-0.29; 95% CI，-0.52至-0.06，P = 0.014），HbA 1c（-0.37; 95%CI，-0.59至-0.14，P = 0.001），SBP（-0.16：95%CI，-0.29至-0.03，P = 0.016），DBP（-0.27，95%CI = -0.41至-0.12，P < 0.001）。干预组和对照组之间HDL-c（0.05; 95%CI，-0.10至0.21; P = 0.503）和LDL-c（-0.14; 95%CI，-0.29至0.02; P = 0.092）无差异。荟萃分析发现，生活方式干预对已知与2型糖尿病患者心血管疾病发展相关的风险因素具有显着益处。(C)2015作者爱思唯尔公司出版这是一个在CC BY-NC-ND许可证下的开放获取文章（http：//creativecommons.org/licenses/by-nc-nd/3.0/）。
Objective. The effect of lifestyle intervention on clinical risk factors in patients with type 2 diabetes is unclear. The aim of this meta-analysis was to evaluate the effects of comprehensive lifestyle change, such as diet, exercise, and education, on clinical markers that are risk-factors for cardiovascular disease in patients with type 2 diabetes.Methods. We searched Medline, Cochrane, EMBASE, and Google Scholar (up to August 31, 2013) for randomized controlled trials that compared standard of care (control group) with treatment regimens that included changes in lifestyle (intervention group). The primary outcome was reduction in risk factors of cardiovascular disease including body mass index (BMI), glycated hemoglobin (HbA1c), systolic blood pressure (SBP), diastolic blood pressure (DBP), high-density lipoprotein cholesterol (HDL-c), and low-density lipoprotein cholesterol (LDL-c).Results. A total of 16 studies were included in the meta-analysis. The standardized difference in means of change from baseline significantly favored the intervention compared with the control group in BMI (-0.29; 95% CI, -0.52 to -0.06, P = 0.014), HbA1c (-0.37; 95% CI, -0.59 to -0.14, P = 0.001), SBP (-0.16: 95% CI, -0.29 to -0.03, P = 0.016), DBP (-0.27, 95% CI = -0.41 to -0.12, P < 0.001). There was no difference between the intervention and control groups in HDL-c (0.05; 95% CI, -0.10 to 0.21; P = 0.503) and LDL-c (-0.14; 95% CI, -0.29 to 0.02; P = 0.092).Conclusions. The meta-analysis found that lifestyle intervention showed significant benefit in risk factors that are known to be associated with development of cardiovascular disease in patients with type 2 diabetes. (C) 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).