Results of radiosurgery for brain stem arteriovenous malformations
Results of radiosurgery for brain stem arteriovenous malformations
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DOI：
10.1136/jnnp.68.5.563
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发表时间：
2000-05-01
影响因子：
11
通讯作者：
Kirino, T
中科院分区：
文献类型：
--
作者：
Kurita, H;Kawamoto, S;Kirino, T
目的评估放射外科治疗脑干动静脉畸形（AVM）的治疗结果，并寻求最佳剂量和治疗体积处方为这些vaselics. Methods的临床和放射学资料的30例连续脑干AVM伽玛刀治疗的平均随访期为52.2个月进行了回顾性分析。有26例患者既往出血，21例神经功能缺损。17例AVM位于中脑，11例位于围栏，2例位于延髓。病灶均较小，多平面MRI或CT横断面上轴向成分占脑干实质面积小于1/3。病灶的平均直径为1.26 cm，脑干实质内的病灶体积范围为0.1至2.0 cm（3）。AVM边缘的平均辐射剂量为18.4戈伊.结果-3年闭塞率为52.2%，标准剂量（最小靶剂量，18- 20戈伊）治疗的病例为69.4%，低剂量治疗的病例为14.3%（
Objective-To assess the treatment results of radiosurgery for brain stem arteriovenous malformations (AVMs) and to seek optimal dose and treatment volume prescription for these lesions.Methods-The clinical and radiological data of 30 consecutive patients with brain stem AVM treated with gamma knife radiosurgery were retrospectively reviewed with a mean follow up period of 52.2 months. There were 26 patients with previous haemorrhages and 21 with neurological deficit. Seventeen AVMs were located in the midbrain, 11 in the pens, and two in the medulla oblongata. All of the lesions were small with the intra-axial component occupying less than one third of the area of brain stem parenchyma on axial section of multiplaner MRI or CT. The mean diameter of the nidus was 1.26 cm, and the nidus volume within the brain stem parenchyma ranged from 0.1 to 2.0 cm(3). The mean radiation dose to the AVM margin was 18.4 Gy.Results-The actuarial 3 year obliteration rate was 52.2%; 69.4% in cases treated with standard doses (minimum target dose, 18-20Gy), and 14.3% in cases treated with low doses (