Allostery in the LacI/GalR family: variations on a theme.
Allostery in the LacI/GalR family: variations on a theme.
复制标题
DOI：
10.1016/j.mib.2009.01.009
复制
发表时间：
2009-04
影响因子：
5.4
通讯作者：
Matthews, Kathleen S.
中科院分区：
文献类型：
--
作者：
Swint-Kruse, Liskin;Matthews, Kathleen S.
The lactose repressor protein (LacI) was among the very first genetic regulatory proteins discovered, and more than 1000 members of the bacterial LacI/GalR family are now identified. LacI has been the prototype for understanding how transcription is controlled using small metabolites to modulate protein association with specific DNA sites. This understanding has been greatly expanded by the study of other LacI/GalR homologues. A general picture emerges in which the conserved fold provides a scaffold for multiple types of interactions —including oligomerization, small molecule binding, and protein•protein binding — that in turn influence target DNA binding and thereby regulate mRNA production. Although many different functions have evolved from this basic scaffold, each homologue retains functional flexibility: For the same protein, different small molecules can have disparate impact on DNA binding and hence transcriptional outcome. In turn, binding to alternative DNA sequences may impact the degree of allosteric response. Thus, this family exhibits a symphony of variations by which transcriptional control is achieved.
登录
查看更多内容
影响因子：
56.9
作者：
Elf, Johan;Li, Gene-Wei;Xie, X. Sunney
通讯作者：
Xie, X. Sunney
影响因子：
5.6
作者：
Glasfeld, A;Koehler, AN;Brennan, RG
通讯作者：
Brennan, RG
影响因子：
2.9
作者：
Falcon, CM;Matthews, KS
通讯作者：
Matthews, KS
影响因子：
64.5
作者：
Kallipolitis, BH;NorregaardMadsen, M;ValentinHansen, P
通讯作者：
ValentinHansen, P
DOI：
10.1016/j.bbapap.2007.03.020
发表时间：
2007-06-01
影响因子：
3.2
作者：
Loll, Bernhard;Saenger, Wolfram;Biesiadka, Jacek
通讯作者：
Biesiadka, Jacek