Capecitabine-induced leukocytoclastic vasculitis under neoadjuvant chemotherapy for locally advanced colorectal cancer
Capecitabine-induced leukocytoclastic vasculitis under neoadjuvant chemotherapy for locally advanced colorectal cancer
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DOI：
10.3978/j.issn.2078-6891.2015.003
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发表时间：
2015-06-01
影响因子：
2.1
通讯作者：
Wolff, Robert A.
中科院分区：
文献类型：
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作者：
Al-Shamsi, Humaid O.;Kee, Bryan K.;Wolff, Robert A.
我们描述了一例卡培他滨诱导的局部晚期直肠癌患者在卡培他滨治疗的新辅助同步放化疗下的白细胞破裂性血管炎。开始使用卡培他滨5天后，患者四肢出现瘙痒性斑疹丘疹，与血管炎一致，皮肤活检证实无任何全身受累迹象。服用卡培他滨，局部类固醇治疗皮疹，皮疹和瘙痒完全消失。由于缺乏其他替代化疗方案和皮肤仅累及血管炎，卡培他滨被重新引入。两天后，患者出现相同的黄斑丘疹，分布相似。泼尼松开始使用，卡培他滨继续使用，皮疹完全消退。患者成功完成了她的治愈性新辅助放化疗治疗，而无需永久停用卡培他滨。
We describe a case of capecitabine-induced leukocytoclastic vasculitis in a patient with locally advanced rectal cancer under curative neoadjuvant concurrent chemoradiation using capecitabine. After 5 days of the initiation of capecitabine the patient developed a pruritic maculopapular rash in her extremities consistent with vasculitis which was confirmed on skin biopsy without any signs of systemic involvement. Capecitabine was held and the rash was treated with topical steroids with complete resolution of both rash and pruritus. Due to a lack of other alternative chemotherapeutic options and the cutaneous-only involvement of vasculitis, the capecitabine was re-introduced. Two days later, the patient developed an identical maculopapular rash with a similar distribution. Prednisone was initiated while the capecitabine was continued with complete resolution of the rash. The patient successfully completed her curative neoadjuvant chemoradiation therapy treatment without the need to permanently discontinue the capecitabine.