Immediate‐type hypersensitivity to reactive dyes
Immediate‐type hypersensitivity to reactive dyes
复制标题
对活性染料的速发型超敏反应
DOI：
--
复制
发表时间：
1978
期刊：
影响因子：
--
通讯作者：
S. Ojanen
中科院分区：
文献类型：
--
作者：
K. Alanko;H. Keskinen;F. Björkstén;S. Ojanen
近年来，活性染料得到了广泛的应用。本文报告了4例对这些化合物的即时性职业性过敏。所有患者都有哮喘和过敏性鼻炎的症状，并已称重染料至少2年。皮肤点刺试验呈阳性，鼻腔和支气管刺激也产生了阳性的即时反应。放射过敏吸附试验可证明至少一种染料具有较高的血清特异性IgE效价。对特异性IgE的鉴定表明，超敏反应的机制是免疫性的，活性染料可能作为半抗原。
Reactive dyes have gained extensive use in recent years. This paper reports four cases of immediate‐type occupational allergy to these compounds. All the patients had had symptoms of asthma and allergic rhinitis, and had been weighing dyes for a minimum of 2 years. The skin prick tests were positive, and nasal and bronchial provocation challenges also produced positive immediate reactions. A high serum titre of specific IgE could be demonstrated for at least one dye by the radioallergosorbent test. The identification of specific IgE shows that the mechanism of the hypersensitivity is immunological, reactive dyes acting probably as haptens.