Interrenal development and function in zebrafish
Interrenal development and function in zebrafish
复制标题
DOI：
10.1016/j.mce.2021.111372
复制
发表时间：
2021-07-20
影响因子：
4.1
通讯作者：
Krone, Nils P.
中科院分区：
文献类型：
--
作者：
Bacila, Irina;Cunliffe, Vincent T.;Krone, Nils P.
在这篇文章中，我们旨在提供斑马鱼肾间发育和功能的概述，以及其在基础和转化研究中的贡献。对PubMed数据库的搜索确定了过去20年发表的41篇相关论文。基于所确定的共同主题，我们讨论了肾间腺的器官发生及其功能发育，并回顾了斑马鱼类固醇发生的已知基因。我们还概述了类固醇生物合成中特定缺陷的后果，如基因工程斑马鱼模型的证据所揭示的，包括cyp11a2， cyp21a2, hsd3b1， cyp11c1和fdx1b缺乏症。最后，我们总结了不同化学物质和环境因素对甾体生成的影响。我们的回顾强调了斑马鱼作为探索基础科学和人类疾病重要领域的研究模型的效用，特别是在分子生物学领域快速技术进步的当前背景下。
In this article we aim to provide an overview of the zebrafish interrenal development and function, as well as a review of its contribution to basic and translational research. A search of the PubMed database identified 41 relevant papers published over the last 20 years. Based on the common themes identified, we discuss the organogenesis of the interrenal gland and its functional development and we review what is known about the genes involved in zebrafish steroidogenesis. We also outline the consequences of specific defects in steroid biosynthesis, as revealed by evidence from genetically engineered zebrafish models, including cyp11a2, cyp21a2, hsd3b1, cyp11c1 and fdx1b deficiency. Finally, we summarise the impact of different chemicals and environmental factors on steroidogenesis. Our review highlights the utility of zebrafish as a research model for exploring important areas of basic science and human disease, especially in the current context of rapid technological progress in the field of Molecular Biology.