Quantitative analysis of perinatal rodent oligodendrocyte lineage progression and its correlation with human
Quantitative analysis of perinatal rodent oligodendrocyte lineage progression and its correlation with human
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DOI：
10.1016/s0014-4886(03)00032-3
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发表时间：
2003-06-01
影响因子：
5.3
通讯作者：
Back, SA
中科院分区：
文献类型：
--
作者：
Craig, A;Luo, NL;Back, SA
在围产期大鼠或小鼠中建立一种能重现人类围产期白质损伤（脑室周围白质软化）主要特征的啮齿动物模型，一直因不确定啮齿动物中与早产儿脑白质发育在时间上相符的发育窗口而受阻。我们最近确定了人类脑白质中少突胶质细胞（OL）谱系的进展，发现晚期OL祖细胞（前OL）在脑室周围白质软化的整个高风险期占主导地位[《神经科学杂志》2001年第21期，1302 - 1312页]。在此，我们确定了围产期大鼠和小鼠在何时各自呈现出与早产儿脑白质相似的OL阶段分布。大鼠和小鼠在出生后第2天（P2）前OL丰富。到出生后第7天（P7），两种动物都出现大量OL成熟，且与早期髓鞘形成的开始时间一致。P2时白质中的前OL和未成熟OL从中线向外侧呈梯度成熟。这可能为围产期白质对损伤易感性的区域差异提供了解释。我们提出，OL谱系进展的顺序是一种有用的方法，可用于估计围产期啮齿动物中与人类脑白质发育窗口相符的白质成熟发育窗口。这些研究支持啮齿动物白质损伤的易损期集中在P2左右，此后应随着髓鞘形成的开始而降低。（C）2003年爱思唯尔科学（美国）。保留所有权利。
The development of a rodent model in the perinatal rat or mouse that reproduces the principal features of human perinatal white matter injury (periventricular leukomalacia) has been hampered by uncertainty about the developmental window in the rodent that coincides temporally with cerebral white matter development in the premature infant. We recently determined oligodendrocyte (OL) lineage progression in human cerebral white matter and found that the late OL progenitor (preOL) predominates throughout the high-risk period for periventricular leukomalacia [J. Neurosci. 21(2001), 1302-1312]. Here, we determined in the perinatal rat and mouse when each species displays a distribution of OL stages that is similar to the premature human cerebral white matter. PreOLs are abundant in the rat and mouse at P2. By P7, extensive OL maturation occurs in both species and coincides with the onset of early myelination. PreOLs and immature OLs mature in the P2 white matter along a medial to lateral gradient. This may provide an explanation for regional variation in the susceptibility of perinatal white matter to injury. We propose that the sequence of OL lineage progression is a useful means to estimate developmental windows of white matter maturation in perinatal rodents that coincide with those of developing human cerebral white matter. These studies support that the vulnerable period for white matter injury in the rodent is centered around P2 and should decline thereafter, coincident with the onset of myelination. (C) 2003 Elsevier Science (USA). All rights reserved.