The kidney papilla is a stem cells niche
The kidney papilla is a stem cells niche
复制标题
DOI：
10.1007/s12015-006-0046-3
复制
发表时间：
2006-01-01
期刊：
影响因子：
--
通讯作者：
Oliver, Juan A.
中科院分区：
文献类型：
--
作者：
Al-Awqati, Qais;Oliver, Juan A.
干细胞的特点是周期短，这使我们能够在成熟的肾脏中识别出这样的细胞。这些推定的干细胞主要位于肾小管外，并集中在肾乳头中，可能在乳头的尿上皮下。这些细胞的克隆分析表明，它们可以分化成上皮细胞、神经元细胞和其他未鉴定的细胞。诱导缺血性肾功能衰竭导致这些乳头状细胞增殖增加。将这些细胞注射到肾被膜下，导致它们并入各种小管节段。很可能这些干细胞感觉到来自皮质的“损伤"信号，导致增殖，然后迁移到损伤部位。
Stem cells are characterized by low cycle time, which has allowed us to identify such cells in the mature kidney. These putative stem cells are located mostly outside the renal tubule and are concentrated in the papilla of the kidney potentially under the urinary epithelium of the papilla. Clonal analysis of these cells shows that they can differentiate into epithelial, neuronal, and other uncharacterized cells. Induction of ischemic renal failure resulted in increased proliferation of these papillary cells. Injection of these cells under the renal capsule led to their incorporation into various tubule segments. It is likely that these stem cells sense a '' damage '' signal from the cortex resulting in proliferation followed by migration to the site of injury.