Obesity or Overweight, a Chronic Inflammatory Status in Male Reproductive System, Leads to Mice and Human Subfertility.
Obesity or Overweight, a Chronic Inflammatory Status in Male Reproductive System, Leads to Mice and Human Subfertility.
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肥胖或超重是男性生殖系统的慢性炎症状态，导致小鼠和人类生育能力低下
DOI：
10.3389/fphys.2017.01117
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发表时间：
2017
影响因子：
4
通讯作者：
Ding Z
中科院分区：
文献类型：
--
作者：
Fan W;Xu Y;Liu Y;Zhang Z;Lu L;Ding Z
肥胖通常伴随着全身的慢性炎症，并且总是与代谢和血管改变引起的症状相关。另一方面，男性生殖道的慢性炎症状态可能直接损害精子发生，甚至与男性生育能力低下有关。然而，肥胖引起的慢性炎症是否会损害男性生殖道的精子发生尚不清楚。为了解决这个问题，我们使用了高脂肪饮食（HFD）诱导的肥胖小鼠模型，并从临床招募了肥胖患者。我们在肥胖小鼠的睾丸、附睾、精囊、前列腺和血清等生殖道组织中检测到肿瘤坏死因子（TNF-α）、白细胞介素-6 （IL-6）和nod样受体家族pyrin domain -3 （NLRP3）水平升高。血清免疫球蛋白G （IgG）和皮质酮水平显著高于对照组。此外，受TNF-α调控的信号因子p38、核因子-κB （NF-κB）、Jun n -末端激酶（JNK）、细胞外信号调节激酶（ERK）及其磷酸化状态以及炎性小体蛋白NLRP3在睾丸中的表达水平较高。对于超重和肥胖的男性患者，在他们的精浆中也观察到TNF-α和IL-6水平的升高。此外，TNF-α和IL-6水平与BMI呈正相关，而与精子浓度和活力呈负相关。总之，男性生育能力的损害可能源于肥胖个体男性生殖道的慢性炎症状态。
Obesity is frequently accompanied with chronic inflammation over the whole body and is always associated with symptoms that include those arising from metabolic and vascular alterations. On the other hand, the chronic inflammatory status in the male genital tract may directly impair spermatogenesis and is even associated with male subfertility. However, it is still unclear if the chronic inflammation induced by obesity damages spermatogenesis in the male genital tract. To address this question, we used a high fat diet (HFD) induced obese mouse model and recruited obese patients from the clinic. We detected increased levels of tumor necrosis factor (TNF-α), interleukin-6 (IL-6), and NOD-like receptor family pyrin domain containing-3 (NLRP3) in genital tract tissues including testis, epididymis, seminal vesicle, prostate, and serum from obese mice. Meanwhile, the levels of immunoglobulin G (IgG) and corticosterone were significantly higher than those in the control group in serum. Moreover, signal factors regulated by TNF-α, i.e., p38, nuclear factor-κB (NF-κB), Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK), and their phosphorylated status, and inflammasome protein NLRP3 were expressed at higher levels in the testis. For overweight and obese male patients, the increased levels of TNF-α and IL-6 were also observed in their seminal plasma. Furthermore, there was a positive correlation between the TNF-α and IL-6 levels and BMI whereas they were inversely correlated with the sperm concentration and motility. In conclusion, impairment of male fertility may stem from a chronic inflammatory status in the male genital tract of obese individuals.
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影响因子：
2.9
作者：
Hueston, Cara M.;Deak, Terrence
通讯作者：
Deak, Terrence
信号通路调节血stis屏障。
DOI：
10.1016/j.biocel.2012.12.009
发表时间：
2013-03
期刊：
The international journal of biochemistry & cell biology
影响因子：
--
作者：
Lie PP;Cheng CY;Mruk DD
通讯作者：
Mruk DD
影响因子：
9.8
作者：
Li, Hong;Lelliott, Christopher;Michaelsson, Erik
通讯作者：
Michaelsson, Erik
影响因子：
2.4
作者：
Bachir, Bassel G.;Jarvi, Keith
通讯作者：
Jarvi, Keith
DOI：
10.1016/j.jnutbio.2011.07.002
发表时间：
2012-10
期刊：
The Journal of nutritional biochemistry
影响因子：
--
作者：
Liu Z;Brooks RS;Ciappio ED;Kim SJ;Crott JW;Bennett G;Greenberg AS;Mason JB
通讯作者：
Mason JB