Green fabrication of agar-conjugated Fe3O4 magnetic nanoparticles
Green fabrication of agar-conjugated Fe3O4 magnetic nanoparticles
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DOI：
10.1088/0957-4484/21/44/445601
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发表时间：
2010-11-05
期刊：
影响因子：
3.5
通讯作者：
Chang, C. W.
中科院分区：
文献类型：
--
作者：
Hsieh, S.;Huang, B. Y.;Chang, C. W.
磁性纳米颗粒在基础研究和新兴应用方面都具有重要意义。在生物医学领域，磁铁矿(Fe3O4)已显示出作为基于热疗的肿瘤治疗的前景。然而，制备合适的增溶磁性纳米颗粒是具有挑战性的，主要是由于团聚和较差的生物相容性。因此，需要在纳米Fe3O4表面包覆生物相容性稳定剂的方法。我们报道了一种新的方法，通过在琼脂凝胶样品的孔内共沉淀法制备纳米Fe3O4。然后将渗透的琼脂凝胶干燥并研磨成粉末，得到琼脂偶联的Fe3O4纳米颗粒。用X射线衍射仪、傅里叶变换红外光谱、热重分析、透射电子显微镜和SQUID对样品进行了表征。这种制备包覆琼脂的Fe3O4纳米粒子的方法对环境友好，价格低廉，可扩展。
Magnetic nanoparticles are of great interest both for fundamental research and emerging applications. In the biomedical field, magnetite (Fe3O4) has shown promise as a hyperthermia-based tumor therapeutic. However, preparing suitable solubilized magnetite nanoparticles is challenging, primarily due to aggregation and poor biocompatibility. Thus methods for coating Fe3O4 NPs with biocompatible stabilizers are required. We report a new method for preparing Fe3O4 nanoparticles by co-precipitation within the pores of agar gel samples. Permeated agar gels were then dried and ground into a powder, yielding agar-conjugated Fe3O4 nanoparticles. Samples were characterized using XRD, FTIR, TGA, TEM and SQUID. This method for preparing agar-coated Fe3O4 nanoparticles is environmentally friendly, inexpensive and scalable.