Individual differences in salivary cortisol: Associations with common over-the-counter and prescription medication status in infants and their mothers
Individual differences in salivary cortisol: Associations with common over-the-counter and prescription medication status in infants and their mothers
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DOI：
10.1016/j.yhbeh.2006.03.014
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发表时间：
2006-08-01
影响因子：
3.5
通讯作者：
Blair, Clancy
中科院分区：
文献类型：
--
作者：
Hibel, Leah C.;Granger, Douglas A.;Blair, Clancy
本研究的目的是描述使用普通非处方药（OTC）和处方药与婴儿及其母亲唾液皮质醇个体差异之间的关联。参与者是1020名母亲和852名婴儿（52.5%男孩;年龄5.03-13.44个月），来自经济困难和种族多样化的家庭（38.4%非洲裔美国人），他们在婴儿参与一系列具有挑战性的任务之前，20和40分钟后捐赠唾液样本。随后测定样本（N = 5616）的皮质醇。对婴儿的药物信息进行单独的内容分析（例如，出牙凝胶、非甾体抗炎药、对乙酰氨基酚、减充血剂）和母亲（例如，麻醉药、抗抑郁药、抗精神病药、避孕药、糖皮质激素）。大部分婴儿（44%）和大多数母亲（57.5%）在过去48小时内至少使用过一种药物（范围0-4）。最常见的是对乙酰氨基酚（例如，泰诺（R））和感冒药（例如，减充血剂）和母亲的避孕药和对乙酰氨基酚。与未服用任何药物的婴儿相比，服用对乙酰氨基酚的婴儿对挑战任务的皮质醇反应不太明显。服用口服或透皮避孕药和乙酰水杨酸的母亲的皮质醇水平较高（例如，阿司匹林），但服用纯激动剂阿片类药物的母亲较低（例如，奥施康定（R））与不服用任何药物的母亲相比。在控制了采样时间、发热、母亲焦虑和抑郁、婴儿气质、种族、社会经济地位和健康状况后，这些与药物相关的差异仍然显著。提供的建议，以引导研究人员明确这些潜在的来源，唾液皮质醇的非系统误差方差。(c)2006年爱思唯尔公司All rights reserved.
The purpose of the present study was to describe associations between the use of common over-the-counter (OTC) and prescription medications with individual differences in salivary cortisol in infants and their mothers. Participants were 1020 mothers and 852 infants (52.5% boys; ages 5.03-13.44 months) from economically disadvantaged and ethnically diverse families (38.4% African American) who donated saliva samples before, 20 and 40 min after infants participated in a series of challenging tasks. Samples (N = 5616) were later assayed for cortisol. Medication information was content analyzed separately for infants (e.g., teething gels, nonsteroidal anti-inflammatory drugs, acetaminophen, decongestants) and mothers (e.g., narcotics, antidepressants, antipsychotics, contraceptives, glucocorticoids). A large percentage of infants (44%) and the majority of mothers (57.5%) had used at least one medication (range 0-4) in the previous 48 h. Most frequent were acetaminophen (e.g., Tylenol (R)) and cold medications (e.g., decongestants) for infants and contraceptives and acetaminophen for mothers. Compared to infants not taking any medications, cortisol reactivity to the challenge tasks was less pronounced for infants taking acetaminophen. Cortisol levels were higher for mothers taking oral or transdermal contraceptives and acetylsalicylic acid (e.g., Aspirins) but lower for mothers taking pure agonist opioids (e.g., Oxycontin (R)) compared to mothers not taking any medications. These medication-related differences remained significant after controlling for sampling time, fever, maternal anxiety and depression, infant temperament, ethnicity, SES, and health status. Recommendations are provided to steer investigators clear of these potential sources of unsystematic error variance in salivary cortisol. (c) 2006 Elsevier Inc. All rights reserved.