Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice
Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice
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DOI：
10.1126/science.1101678
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发表时间：
2004-10-29
期刊：
影响因子：
56.9
通讯作者：
Gingrich, JA
中科院分区：
文献类型：
--
作者：
Ansorge, MS;Zhou, MM;Gingrich, JA
5-羟色胺转运体（5-HTT）表达减少与人类和啮齿动物的异常情感和焦虑样症状有关，但这种作用的机制尚不清楚。在发育早期用常用的5-羟色胺选择性再摄取抑制剂ftuoxetine短暂抑制5-HTT，在成年小鼠中产生异常的情绪行为。这种效应模拟了5-HTT表达遗传缺陷小鼠的行为表型。这些研究结果表明，5-羟色胺在大脑系统的成熟中起着关键作用，该系统调节成人的情感功能，并提出了一种发展机制来解释低表达的5-HTT启动子等位基因如何增加对精神疾病的易感性。
Reduced serotonin transporter (5-HTT)-expression is associated with abnormal affective and anxiety-like symptoms in humans and rodents, but the mechanism of this effect is unknown. Transient inhibition of 5-HTT during early development with ftuoxetine, a commonly used serotonin selective reuptake inhibitor, produced abnormal emotional behaviors in adult mice. This effect mimicked the behavioral phenotype of mice genetically deficient in 5-HTT expression. These findings indicate a critical rote of serotonin in the maturation of brain systems that modulate emotional function in the adult and suggest a developmental mechanism to explain how low-expressing 5-HTT promoter alleles increase vulnerability to psychiatric disorders.