A case of refractory chronic rhinosinusitis with anti-desmoglein 3 IgG4 autoantibody.
A case of refractory chronic rhinosinusitis with anti-desmoglein 3 IgG4 autoantibody.
复制标题
抗桥粒芯糖蛋白 3 IgG4 自身抗体难治性慢性鼻鼻窦炎一例。
DOI：
10.1016/j.alit.2017.04.009
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Mitsuya Suzuki
中科院分区：
文献类型：
--
作者：
Y. Ota;F. Ishikawa;Toshiya Sato;N. Hiruta;M. Kitamura;H. Yokota;Y. Ikemiyagi;H. Bujo;M. Fujiwara;Mitsuya Suzuki
免疫球蛋白（IG）G4相关疾病（IgG 4-RD）是一种全身性、难治性、慢性炎症性疾病，其特征为高血清IgG 4水平和IgG 4阳性浆细胞浸润和纤维化的组织病理学发现。1，2虽然最近的报道已经记录了伴有IgG 4浸润（IgG 4-CRS）的难治性慢性鼻窦炎（CRS）的病例，3 e5潜在的机制仍然未知。桥粒芯糖蛋白3是寻常天疱疮（PV）的自身抗原，寻常天疱疮是一种自身免疫性起泡粘膜皮肤疾病。6在此，我们首次报道一例难治性CRS伴治疗无效鼻息肉病伴桥粒芯糖蛋白3特异性IgG 4自身抗体浸润。此病例因双侧颌下腺及泪腺肿胀而被诊断为米库利奇病。我们评估了IgG 4-CRS与桥粒芯糖蛋白3自身抗体之间的关系。
Immunoglobulin (Ig) G4-related disease (IgG4-RD) is a systemic, refractory, chronic inflammatory disease characterized by high serum IgG4 levels and histopathological findings of IgG4-positive plasma cell infiltration and fibrosis. 1, 2 Although recent reports have documented cases of refractory chronic rhinosinusitis (CRS) accompanied by IgG4 infiltration (IgG4-CRS), 3 e5 the underlying mechanism remains unknown.Desmoglein 3 is an autoantigen of Pemphigus vulgaris (PV), an autoimmune blistering mucocutaneous disease. 6 Here, for the first time, we report a case of refractory CRS with treatment-recalcitrant nasal polyposis accompanied by infiltration of IgG4 autoantibody specific for desmoglein 3. This case was diagnosed as Mikulicz's disease because of bilateral submandibular and lacrimal glands swelling. We assessed the relationship between IgG4-CRS and desmoglein 3 autoantibody.
DOI：
10.1016/j.jaci.2011.08.037
发表时间：
2011-12
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Tan BK;Li QZ;Suh L;Kato A;Conley DB;Chandra RK;Zhou J;Norton J;Carter R;Hinchcliff M;Harris K;Peters A;Grammer LC;Kern RC;Mohan C;Schleimer RP
通讯作者：
Schleimer RP