Central and peripheral control of sympathoadrenal activity and energy metabolism in rats
Central and peripheral control of sympathoadrenal activity and energy metabolism in rats
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DOI：
10.1016/0031-9384(90)90248-3
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发表时间：
1990-12
影响因子：
2.9
通讯作者：
A. Scheurink;A. Steffens
中科院分区：
文献类型：
--
作者：
A. Scheurink;A. Steffens
本文研究了运动大鼠下丘脑和外周交感神经系统的肾上腺素受体在交感-肾上腺活动、葡萄糖和游离脂肪酸动员中的作用。交感-肾上腺系统两部分之间以及运动中葡萄糖调节因子和FFA动员之间明显的密切关系被下丘脑局部注入肾上腺素能受体拮抗剂或麻醉药物完全阻断。这些实验实际上识别了下丘脑中的特定区域，这些区域将血液中底物水平的信息与大脑高级中心的“中央命令”结合在一起。此外，在给予和不给予选择性肾上腺素受体激动剂和拮抗剂的情况下，运动正常和去肾上腺髓质(Adm)大鼠的实验结果表明，交感神经系统的活动也在外周交感神经末梢的水平上进行调节。特别是，突触前肾上腺素能调节机制可以显著影响NE从交感神经末梢流出。总而言之，数据表明，在运动过程中，交感神经输出的器官特异性组织可能发生在交感神经系统内的不同水平。
The role of adrenoceptors in the hypothalamus and the peripheral sympathetic nervous system in the regulation of sympathoadrenal activity and glucose and FFA mobilization was investigated in exercising rats. Apparent close relations within the two parts of the sympathoadrenal system and between factors that regulate glucose and FFA mobilization during exercise were completely disrupted by local hypothalamic infusions of adrenoceptor antagonists or anesthetic drugs. The experiments actually identified specific areas in the hypothalamus that integrate the information regarding the substrate levels in the blood with the “central command” from higher centers in the brain. Furthermore, the results of experiments with exercising intact and adrenodemedullated (Adm) rats, with and without administration of selective adrenoceptor agonists and antagonists, suggest that the activity of the sympathetic nervous system is also regulated at the level of the peripheral sympathetic nerve endings. In particular, presynaptic adrenergic regulatory mechanisms can markedly influence the outflow of NE from the sympathetic nerve endings. In conclusion, the data show that an organ-specific organization of sympathetic output during exercise may take place at different levels within the sympathetic nervous system.