COVID-19 and Oxidative Stress.
COVID-19 and Oxidative Stress.
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DOI：
10.1134/s0006297920120068
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发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
Zinovkin RA
中科院分区：
文献类型：
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作者：
Chernyak BV;Popova EN;Prikhodko AS;Grebenchikov OA;Zinovkina LA;Zinovkin RA
新型冠状病毒感染COVID-19的发病机制是世界各地积极研究的主题。由SARS-CoV-2引起的COVID-19是一种复杂的疾病，其中病毒与靶细胞的相互作用，免疫系统的作用和身体对这些事件的系统反应密切相关。许多呼吸道病毒感染，包括COVID-19，导致感染细胞死亡，先天免疫反应激活和炎性细胞因子分泌。所有这些过程都与氧化应激的发展有关，氧化应激对病毒感染的发病机制做出了重要贡献。本文综述了与SARS-CoV-2和其他呼吸道病毒感染相关的氧化应激信息。该综述还重点关注了血管内皮在COVID-19发病机制中的参与。
Pathogenesis of the novel coronavirus infection COVID-19 is the subject of active research around the world. COVID-19 caused by the SARS-CoV-2 is a complex disease in which interaction of the virus with target cells, action of the immune system and the body’s systemic response to these events are closely intertwined. Many respiratory viral infections, including COVID-19, cause death of the infected cells, activation of innate immune response, and secretion of inflammatory cytokines. All these processes are associated with the development of oxidative stress, which makes an important contribution to pathogenesis of the viral infections. This review analyzes information on the oxidative stress associated with the infections caused by SARS-CoV-2 and other respiratory viruses. The review also focuses on involvement of the vascular endothelium in the COVID-19 pathogenesis.