Dietary components related to N-nitroso compound formation: a prospective study of adult glioma.
Dietary components related to N-nitroso compound formation: a prospective study of adult glioma.
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DOI：
10.1158/1055-9965.epi-10-0225
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发表时间：
2010-07
期刊：
影响因子：
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通讯作者：
Ward MH
中科院分区：
文献类型：
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作者：
Dubrow R;Darefsky AS;Park Y;Mayne ST;Moore SC;Kilfoy B;Cross AJ;Sinha R;Hollenbeck AR;Schatzkin A;Ward MH
n -亚硝基化合物（NOCs）存在于加工肉类中，是由摄入亚硝酸盐和硝酸盐内源性形成的。内源性NOC的形成可被水果和蔬菜中的亚硝化抑制剂（如维生素C）拮抗，并可被红肉中的血红素促进。据推测，导致高剂量接触NOCs的饮食会增加成人神经胶质瘤的风险。使用比例风险模型，我们在前瞻性NIH-AARP饮食与健康研究的545,770名参与者中验证了这一假设，该研究使用综合食物频率问卷（FFQ）评估基线（1995 - 1996年）的饮食摄入量，并使用简短的FFQ评估12-13岁的饮食摄入量。在2003年的随访期间，585名参与者被诊断出患有神经胶质瘤。我们发现，食用加工肉或红肉、硝酸盐、维生素C或维生素e在神经胶质瘤风险方面没有显著的趋势。我们发现，从植物来源摄入亚硝酸盐有显著的积极趋势（五分位数的风险比[HR] vs. 1.59； 95%可信区间[CI]， 1.20-2.10; p-trend = 0.028），出乎意料的是，水果和蔬菜摄入（HR, 1.42; 95% CI, 1.08-1.86; p-trend = 0.0081）。对饮食摄入量（如亚硝酸盐和维生素C）之间相互作用的研究与对12-13岁饮食的有限分析没有为NOC假说提供支持。我们的研究结果对饮食摄入和成人神经胶质瘤风险之间的NOC假说提出了质疑。需要进一步研究早期饮食、成人从植物中摄入亚硝酸盐以及成人摄入水果和蔬菜与成年胶质瘤风险的关系。
N-nitroso compounds (NOCs) are found in processed meat and are formed endogenously from intake of nitrite and nitrate. Endogenous NOC formation is antagonized by nitrosation inhibitors in fruit and vegetables (e.g., vitamin C) and promoted by heme in red meat. It has been hypothesized that a diet resulting in high exposure to NOCs increases adult glioma risk. Using proportional hazards models, we tested this hypothesis among 545,770 participants in the prospective NIH-AARP Diet and Health Study, which assessed dietary intake at baseline (1995–96) with a comprehensive food frequency questionnaire (FFQ) and at ages 12–13 years with an abbreviated FFQ. During follow-up through 2003, 585 participants were diagnosed with glioma. We found no significant trends in glioma risk for consumption of processed or red meat, nitrate, or vitamin C or E. We found significant positive trends for nitrite intake from plant sources (hazard ratio [HR] for quintile 5 vs. 1, 1.59; 95% confidence interval [CI], 1.20–2.10; p-trend = 0.028) and, unexpectedly, for fruit and vegetable intake (HR, 1.42; 95% CI, 1.08–1.86; p-trend = .0081). Examination of interactions between dietary intakes (e.g., nitrite and vitamin C) and a limited analysis of diet at ages 12–13 provided no support for the NOC hypothesis. Our results cast doubt on the NOC hypothesis in relation to dietary intake and adult glioma risk. Further work is needed on early life diet, adult intake of nitrite from plant sources, and adult intake of fruit and vegetables in relation to adult glioma risk.