Improved outcome of allogeneic bone marrow transplantation due to breastfeeding-induced tolerance to maternal antigens
Improved outcome of allogeneic bone marrow transplantation due to breastfeeding-induced tolerance to maternal antigens
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DOI：
10.1182/blood-2008-05-155283
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发表时间：
2009-02-19
期刊：
影响因子：
20.3
通讯作者：
Teshima, Takanori
中科院分区：
文献类型：
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作者：
Aoyama, Kazutoshi;Koyama, Motoko;Teshima, Takanori
后代在怀孕期间暴露于非遗传性母源抗原（NIMAs）可能对以后的移植有影响。通过小鼠模型，我们最近发现，从暴露于nima的后代到母亲的骨髓移植（BMT）导致移植物抗宿主病（GVHD）的减少。由于后代在出生后也可以通过母乳喂养接触到NIMA，因此我们测试了母乳是否可以介导NIMA的耐受性效应。我们发现，仅通过母乳喂养口服暴露于NIMAs就足以减少GVHD，并且需要在子宫内暴露于NIMAs才能最大限度地减少GVHD。在哺乳期给小鼠注射CD25单克隆抗体后，耐受乳效应消失，提示CD4(+)CD25（+）调节性T细胞依赖机制。我们的研究结果表明，母乳喂养对移植结果的影响是以前未知的。(血。2009;113:1829 - 1833)
Exposure of offspring to noninherited maternal antigens (NIMAs) during pregnancy may have an impact on transplantations performed later in life. Using a mouse model, we recently showed that bone marrow transplantation (BMT) from NIMA-exposed offspring to the mother led to a reduction of graft-versus-host disease (GVHD). Since offspring can also be exposed to NIMAs by breastfeeding after birth, we tested whether breast milk could mediate the tolerogenic NIMA effect. We found that oral exposure to NIMAs by breastfeeding alone was sufficient to reduce GVHD, and that in utero exposure to NIMAs is required for maximum reduction of GVHD. The tolerogenic milk effects disappeared when donor mice were injected with CD25 monoclonal antibodies during the lactation period, suggesting a CD4(+)CD25(+) regulatory T cell dependent mechanism. Our results suggest a previously unknown impact of breastfeeding on the outcome of transplantation. (Blood. 2009;113:1829-1833)