Functional Clustering Drives Encoding Improvement in a Developing Brain Network during Awake Visual Learning
Functional Clustering Drives Encoding Improvement in a Developing Brain Network during Awake Visual Learning
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DOI：
10.1371/journal.pbio.1001236
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发表时间：
2012-01-01
期刊：
影响因子：
9.8
通讯作者：
Haas, Kurt
中科院分区：
文献类型：
--
作者：
Podgorski, Kaspar;Dunfield, Derek;Haas, Kurt
感官体验推动发育中的神经元具有显着的结构和功能可塑性。然而，为了使单神经元的可塑性以最佳方式改善感觉信息的全网络编码，必须协调神经元之间的变化，以确保有效地表示全方位的刺激。我们利用双光子钙成像同时监测 100 多个神经元的诱发活动，研究了在运动刺激的视觉训练过程中发育中的非洲爪蟾顶盖的网络水平变化。训练会导致神经元反应和相互作用发生特定刺激的变化，从而改善群体编码。这种可塑性是空间结构的，增加了附近神经元之间的调谐曲线相似性和相互作用，并减少了远处神经元之间的相互作用。训练不会改善单个响应类似的神经元簇的编码，但会改善跨簇的编码，这表明整个网络的协调可塑性。 NMDA 受体阻断可防止协调可塑性、减少聚类并消除整个网络编码改进。我们得出的结论是，NMDA 受体支持经验依赖的网络自组织，允许对各种刺激进行有效的群体编码。
Sensory experience drives dramatic structural and functional plasticity in developing neurons. However, for single-neuron plasticity to optimally improve whole-network encoding of sensory information, changes must be coordinated between neurons to ensure a full range of stimuli is efficiently represented. Using two-photon calcium imaging to monitor evoked activity in over 100 neurons simultaneously, we investigate network-level changes in the developing Xenopus laevis tectum during visual training with motion stimuli. Training causes stimulus-specific changes in neuronal responses and interactions, resulting in improved population encoding. This plasticity is spatially structured, increasing tuning curve similarity and interactions among nearby neurons, and decreasing interactions among distant neurons. Training does not improve encoding by single clusters of similarly responding neurons, but improves encoding across clusters, indicating coordinated plasticity across the network. NMDA receptor blockade prevents coordinated plasticity, reduces clustering, and abolishes whole-network encoding improvement. We conclude that NMDA receptors support experience-dependent network self-organization, allowing efficient population coding of a diverse range of stimuli.