Arsenic Trioxide-loaded nanoparticles Enhance the Chemosensitivity of Gemcitabine in Pancreatic Cancer via Reversal of Pancreatic Stellate Cells Desmoplasia through Targeting AP4/Galectin-1 Pathway
Arsenic Trioxide-loaded nanoparticles Enhance the Chemosensitivity of Gemcitabine in Pancreatic Cancer via Reversal of Pancreatic Stellate Cells Desmoplasia through Targeting AP4/Galectin-1 Pathway
复制标题
三氧化二砷纳米颗粒通过靶向 AP4/Galectin-1 途径逆转胰腺星状细胞结缔组织形成，增强吉西他滨对胰腺癌的化疗敏感性
DOI：
10.1039/d2bm01039a
复制
发表时间：
2022
影响因子：
6.6
通讯作者：
Jiajia Li
中科院分区：
文献类型：
--
作者：
Yue Zhao;Hanming Yao;Kege Yang;Shiji Han;Shangxiang Chen;Yaqing Li;Shaojie Chen;Kaihong Huang;Guoda Lian;Jiajia Li
ScAb-ATO-NP靶向PSC以增加ATO向PSC的递送效率。ATO通过PI 3 K/AKT/AP 4/galectin-1途径抑制PDAC中PSC的活化，减少ECM的合成，从而增强PDAC的化疗效果。
ScAb-ATO-NPs targets PSCs to increase the delivery efficiency of ATO to PSCs. ATO inhibits the activation of PSCs via PI3K/AKT/AP4/galectin-1 pathway and decreases the synthesis of ECM in PDAC, which enhances the chemotherapy in PDAC.