The Relationship between Prostate Inflammation and Lower Urinary Tract Symptoms: Examination of Baseline Data from the REDUCE Trial
The Relationship between Prostate Inflammation and Lower Urinary Tract Symptoms: Examination of Baseline Data from the REDUCE Trial
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DOI：
10.1016/j.eururo.2007.11.026
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发表时间：
2008-12-01
期刊：
影响因子：
23.4
通讯作者：
Rittmaster, Roger S.
中科院分区：
文献类型：
--
作者：
Nickel, J. Curtis;Roehrborn, Claus G.;Rittmaster, Roger S.
目的：正在进行的REDUCE试验是一项为期4年的3期安慰剂对照研究，旨在确定每日0.5 mg度他雄胺是否可降低活检可检测的前列腺癌的风险。方法：符合条件的男性年龄50-75岁，血清前列腺特异性抗原≥ 2.5 mg/ml和≥ 3.0 ng/ml，
Objective: The ongoing REDUCE trial is a 4-yr, phase 3, placebo-controlled study to determine if daily dutasteride 0.5 mg reduces the risk of biopsy detectable prostate cancer. Prostate biopsies performed in all men prior to entry were centrally reviewed, thus allowing an examination of the relationship between inflammatory changes and lower urinary tract symptoms (LUTS).Methods: Eligible men were aged 50-75 yr, with serum prostate-specific antigen >= 2.5 mg/ml and = 3.0 ng/ml and