A neural representation of categorization uncertainty in the human brain
A neural representation of categorization uncertainty in the human brain
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DOI：
10.1016/j.neuron.2006.01.032
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发表时间：
2006-03-02
期刊：
影响因子：
16.2
通讯作者：
Ferrera, VP
中科院分区：
文献类型：
--
作者：
Grinband, J;Hirsch, J;Ferrera, VP
将视觉对象分类为离散类别（“朋友”与“敌人”;“可食用”与“有毒”）的能力对于生存至关重要，并且是一种基本的认知功能。然而，在人类中还没有发现介导这种功能的皮质基质。为了确定参与刺激分类的大脑区域，我们开发了一个任务，在该任务中，受试者根据变量分类边界对刺激进行分类。心理物理功能被用来定义一个决策变量，分类的不确定性，这是系统地操纵。使用事件相关的功能性MRI，我们发现，在一个额-纹状体-丘脑网络，包括内侧额回，前额叶，腹侧纹状体，丘脑背内侧，调制的分类不确定性的活动。我们发现，这个网络是不同的额顶叶注意力网络，包括额叶和顶叶的眼睛领域，其中的活动是不相关的分类不确定性。
The ability to classify visual objects into discrete categories ("friend" versus "foe"; "edible" versus "poisonous") is essential for survival and is a fundamental cognitive function. The cortical substrates that mediate this function, however, have not been identified in humans. To identify brain regions involved in stimulus categorization, we developed a task in which subjects classified stimuli according to a variable categorical boundary. Psychophysical functions were used to define a decision variable, categorization uncertainty, which was systematically manipulated. Using eevent-related functional MRI, we discovered that activity in a fronto-striatal-thalamic network, consisting of the medial frontal gyrus, anterior insula, ventral striatum, and dorsomedial thalamus, was modulated by categorization uncertainty. We found this network to be distinct from the frontoparietal attention network, consisting of the frontal and parietal eye fields, where activity was not correlated with categorization uncertainty.