Long-term decrease in bladder cancer recurrence with hexaminolevulinate enabled fluorescence cystoscopy.
Long-term decrease in bladder cancer recurrence with hexaminolevulinate enabled fluorescence cystoscopy.
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DOI：
10.1016/j.juro.2012.03.007
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发表时间：
2012-07
期刊：
影响因子：
--
通讯作者：
Burger M
中科院分区：
文献类型：
--
作者：
Grossman HB;Stenzl A;Fradet Y;Mynderse LA;Kriegmair M;Witjes JA;Soloway MS;Karl A;Burger M
We assessed the impact that hexaminolevulinate fluorescence cystoscopic detection of papillary, non-muscle invasive bladder cancer has on long-term recurrence rates. Long-term follow-up was assessed in 551 participants enrolled in a prospective, randomized study of fluorescence cystoscopy for Ta or T1 urothelial bladder cancer. In the original study, 280 patients in the white light cystoscopy group and 271 in the fluorescence cystoscopy group were followed with cystoscopy for 3, 6, and 9 months following the initial resection or until recurrence. A study extension protocol obtained long-term follow-up of these patients. Follow-up information was obtained for 261 of the 280 (93%) participants in the white light group and 255 of the 271 (94%) participants in the fluorescence group. Median follow-up in the white light and fluorescence groups were 53.0 and 55.1 months, respectively. In the white light and fluorescence groups, 83 (31.8%) and 97 (38%) of the participants remained tumor free, respectively. The median recurrence free survival was 9.6 months in the white light group and 16.4 months in the fluorescence group, p = 0.04. The rates of intravesical therapy were similar in the white light (46%) and fluorescence groups (45%). Cystectomy was performed in 22/280 (7.9%) in the white light group and 13/271 (4.8%) in the fluorescence group, p = 0.16. Hexaminolevulinate fluorescence cystoscopy significantly improves long-term bladder cancer recurrence free survival with a trend towards improved bladder preservation.
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影响因子：
6.6
作者：
Schmidbauer, J;Witjes, F;Marberger, M
通讯作者：
Marberger, M
影响因子：
4.5
作者：
Babjuk, M;Soukup, V;Dvorácek, J
通讯作者：
Dvorácek, J
影响因子：
6.6
作者：
Grossman, H. Barton;Gomella, Leonard;Droller, Michael J.
通讯作者：
Droller, Michael J.
影响因子：
2.1
作者：
KRIEGMAIR, M;EHSAN, A;HOFSTETTER, A
通讯作者：
HOFSTETTER, A
影响因子：
--
作者：
Malmstrom, Per-Uno;Hedelin, Hans;Furniss, Jim
通讯作者：
Furniss, Jim