Efficacy of electrical stimulation at frequencies higher than basal rate in canine stomach
Efficacy of electrical stimulation at frequencies higher than basal rate in canine stomach
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DOI：
10.1023/a:1018804128695
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发表时间：
1997-05-01
影响因子：
3.1
通讯作者：
Johnson, B
中科院分区：
文献类型：
--
作者：
Familoni, BO;Abell, TL;Johnson, B
电刺激胃运动的最佳频率仍然是个问题。一些在接近生理频率的胃电刺激（GES）的研究报道了胃电夹带，但在改善运动方面的疗效甚微。在这项研究中，我们研究了在广泛的频率范围内的电刺激在犬模型中引起胃电活动（GEA）和引起收缩的有效性。六只狗的胃，每只植入四对不锈钢电极和两个应变计进行了刺激，频率范围从3到30个周期/分钟。GEA和收缩监测之前和电刺激过程中。还研究了不同频率的GES逆转胰高血糖素作用的能力。GEA在大多数动物中以接近固有速率的频率以及4至5倍的固有速率被夹带。在其他刺激频率下，记录的电控制活动要么保持不变，解耦，或变得节律失调。4 ~ 5倍内频率刺激的收缩反应显著高于接近内频率刺激的收缩反应（P < 0.05）。GES不改变胰高血糖素的作用。刺激频率的4倍的基础率5/分钟引起最大的运动指数的狗。以远高于生理频率的频率进行刺激，作为GES的可能最佳范围，需要进一步研究。
The optimum frequency for electrically stimulating motility in the stomach is still in question. Some studies of gastric electrical stimulation (GES) at near physiologic frequencies have reported gastric electrical entrainment but with little efficacy in improving motility. In this study we examined the effectiveness of electrical stimulation at a broad range of frequencies in entraining gastric electrical activity (GEA) and eliciting contractions in a canine model. The stomachs of six dogs, each implanted with four pairs of stainless steel electrodes and two strain gauges were stimulated at frequencies ranging from 3 to 30 cycles/min. GEA and contractions were monitored before and during electrical stimulation. The ability of GES at different frequencies to reverse the effect of glucagon was also investigated. GEA was entrained in most animals at frequencies close to the intrinsic rate as well as at four to five times the intrinsic rate. At other stimulation frequencies, the recorded electrical control activity either remained unchanged, uncoupled, or became dysrhythmic. Contractile response to stimulation at four to five times the intrinsic rate were significantly higher than those at frequencies close to the intrinsic rate (P < 0.05). GES did not alter the effect of glucagon. Stimulation at a frequency of four times the basal rate of 5/min elicited the largest motility index in dogs. Stimulation at frequencies much higher than the physiologic rate warrants further study as a possible optimum range for GES.