Fluid-structure interaction modeling of calcific aortic valve disease using patient-specific three-dimensional calcification scans
Fluid-structure interaction modeling of calcific aortic valve disease using patient-specific three-dimensional calcification scans
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DOI：
10.1007/s11517-016-1458-0
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发表时间：
2016-11-01
影响因子：
3.2
通讯作者：
Haj-Ali, Rami
中科院分区：
文献类型：
--
作者：
Halevi, Rotem;Hamdan, Ashraf;Haj-Ali, Rami
钙化性主动脉瓣疾病（CAVD）的特征是主动脉瓣尖钙化积聚和增厚，导致狭窄。流体流动剪应力在CAVD进展的启动和调节中的重要性是众所周知的，并且最近已经使用流体-结构相互作用（FSI）模型进行了研究。虽然尖瓣钙化是三维（3D）肿块，但先前发表的FSI模型将其表示为硬化或增厚的二维（2D）尖瓣。本研究采用FSI模型，使用3D患者特异性钙化肿块，研究这些钙化的血流动力学效应。一种新的逆向钙化技术（RCT）被用来模拟不同阶段的钙化生长的钙化密度的空间分布的基础上。RCT用于生成根据患者特定CT扫描重建的3D钙化沉积物。我们的研究结果表明，考虑3D钙化沉积物导致瓣尖主动脉侧的流体剪切应力更高和独特的流体剪切应力分布，这可能对钙化生长速率产生影响。然而，在生长阶段，流动似乎并不影响钙化的几何形状。
Calcific aortic valve disease (CAVD) is characterized by calcification accumulation and thickening of the aortic valve cusps, leading to stenosis. The importance of fluid flow shear stress in the initiation and regulation of CAVD progression is well known and has been studied recently using fluid-structure interaction (FSI) models. While cusp calcifications are three-dimensional (3D) masses, previously published FSI models have represented them as either stiffened or thickened two-dimensional (2D) cusps. This study investigates the hemodynamic effect of these calcifications employing FSI models using 3D patient-specific calcification masses. A new reverse calcification technique (RCT) is used for modeling different stages of calcification growth based on the spatial distribution of calcification density. The RCT is applied to generate the 3D calcification deposits reconstructed from a patient-specific CT scans. Our results showed that consideration of 3D calcification deposits led to both higher fluid shear stresses and unique fluid shear stress distribution on the aortic side of the cusps that may have an impact on the calcification growth rate. However, the flow did not seem to affect the geometry of the calcification during the growth phase.