Neurotransmitter modulation of small-conductance Ca2+-activated K+ channels by regulation of Ca2+ gating.
Neurotransmitter modulation of small-conductance Ca2+-activated K+ channels by regulation of Ca2+ gating.
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通过调节 Ca2+ 门控对小电导 Ca2+ 激活的 K+ 通道进行神经递质调节。
DOI：
10.1016/j.neuron.2008.05.026
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发表时间：
2008-08-14
期刊：
影响因子：
16.2
通讯作者：
Delmas, Patrick
中科院分区：
文献类型：
--
作者：
Maingret, Francois;Coste, Bertrand;Hao, Jizhe;Giamarchi, Aurelie;Allen, Duane;Crest, Marcel;Litchfield, David W.;Adelman, John P.;Delmas, Patrick
Small-conductance Ca2+-activated K+ (SK) channels are widely expressed in neuronal tissues where they underlie post-spike hyperpolarizations, regulate spike-frequency adaptation and shape synaptic responses. SK channels constitutively interact with calmodulin (CaM), which serves as Ca2+ sensor, and with protein kinase CK2 and protein phosphatase 2A, which modulate their Ca2+ gating. By recording coupled activities of Ca2+ and SK2 channels, we showed that SK2 channels can be inhibited by neurotransmitters independently of changes in the activity of the priming Ca2+ channels. This inhibition involves SK2-associated CK2 and results from a 3-fold reduction in the steady-state Ca2+ sensitivity of channel gating. CK2 phosphorylated SK2-bound CaM but not KCNQ2-bound CaM, thereby selectively regulating Ca2+ gating of SK2 channels. We extended these observations to sensory neurons by showing that noradrenaline inhibits SK current and enhances signaling of primary afferent neurons in a CK2- dependent fashion. Hence, neurotransmitter-initiated signaling cascades can dynamically regulate Ca2+ sensitivity of SK channels and directly influence somatic excitability.
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影响因子：
5.3
作者：
Allen, Duane;Fakler, Bernd;Adelman, John P.
通讯作者：
Adelman, John P.
影响因子：
2.9
作者：
Arrigoni, G;Marin, O;Pinna, LA
通讯作者：
Pinna, LA
DOI：
10.1111/j.1749-6632.1999.tb11298.x
发表时间：
1999-01-01
期刊：
MOLECULAR AND FUNCTIONAL DIVERSITY OF ION CHANNELS AND RECEPTORS
影响因子：
--
作者：
Bond, CT;Maylie, J;Adelman, JP
通讯作者：
Adelman, JP
DOI：
10.1085/jgp.200609665
发表时间：
2007-01
期刊：
The Journal of general physiology
影响因子：
--
作者：
Coste B;Crest M;Delmas P
通讯作者：
Delmas P
DOI：
10.1073/pnas.93.4.1486
发表时间：
1996-02-20
影响因子：
11.1
作者：
Bourinet, E;Soong, TW;Snutch, TP
通讯作者：
Snutch, TP