A high‐quality pedigree and genetic markers both reveal inbreeding depression for quality but not survival in a cooperative mammal
A high‐quality pedigree and genetic markers both reveal inbreeding depression for quality but not survival in a cooperative mammal
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高质量的谱系和遗传标记都揭示了近亲繁殖对质量的抑制，但对合作哺乳动物的生存却没有影响
DOI：
10.1111/mec.14570
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发表时间：
2018
影响因子：
4.9
通讯作者：
Hoffman
中科院分区：
文献类型：
--
作者：
Nichols;Hoffman
近交衰退，即密切相关的父母的后代适应性下降，在圈养和野生种群中都很常见，并对保护和交配系统的进化产生重要影响。然而，由于从野生种群中收集谱系和生活史数据的困难，相对较少的研究能够比较近交衰退在生命周期不同阶段的性状。此外，谱系给出了血统相同的基因组的预期比例（IBDg），而理论上，只要有足够的分子标记，就可以直接量化IBDg。因此，我们使用基于谱系的近交系数（fped）和在 35-43 个微卫星上测量的标准化多位点杂合度（sMLH），研究了野生带状猫鼬种群中多种生活史特征的近交抑制。在信息论框架内，我们评估了对 fped 或 sMLH 作为近亲繁殖项的支持，并使用序贯回归来确定 fped 上 sMLH 的残差是否解释了高于和超出 fped 的适应度变化。我们没有发现任何证据表明近亲繁殖会影响生存，无论是在营养独立之前还是之后。相比之下，近亲繁殖与两个质量相关性状（一岁体重和每年雄性繁殖成功率）呈负相关。一岁体重与 fped 相关，但与 sMLH 无关，而雄性年度繁殖成功率最好由 fped 和残余 sMLH 解释。因此，我们的研究不仅揭示了不同性状表现出近交抑郁程度的差异，而且还揭示了谱系和分子标记解释适应性变异的能力的性状特异性差异，并表明对于某些性状，遗传标记可能捕获已实现的IBD高于和超出谱系预期的变异。
Inbreeding depression, the reduced fitness of offspring of closely related parents, is commonplace in both captive and wild populations and has important consequences for conservation and mating system evolution. However, because of the difficulty of collecting pedigree and life‐history data from wild populations, relatively few studies have been able to compare inbreeding depression for traits at different points in the life cycle. Moreover, pedigrees give the expected proportion of the genome that is identical by descent (IBDg) whereas in theory with enough molecular markers realized IBDgcan be quantified directly. We therefore investigated inbreeding depression for multiple life‐history traits in a wild population of banded mongooses using pedigree‐based inbreeding coefficients (fped) and standardized multilocus heterozygosity (sMLH) measured at 35–43 microsatellites. Within an information theoretic framework, we evaluated support for eitherfpedor sMLH as inbreeding terms and used sequential regression to determine whether the residuals of sMLH onfpedexplain fitness variation above and beyondfped. We found no evidence of inbreeding depression for survival, either before or after nutritional independence. By contrast, inbreeding was negatively associated with two quality‐related traits, yearling body mass and annual male reproductive success. Yearling body mass was associated withfpedbut not sMLH, while male annual reproductive success was best explained by bothfpedand residual sMLH. Thus, our study not only uncovers variation in the extent to which different traits show inbreeding depression, but also reveals trait‐specific differences in the ability of pedigrees and molecular markers to explain fitness variation and suggests that for certain traits, genetic markers may capture variation in realized IBDgabove and beyond the pedigree expectation.
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谱系或标记：哪个能更好地估计相关性和近交系数？
影响因子：
1.4
作者：
Jinliang Wang
通讯作者：
Jinliang Wang
交配结构对近交变异的影响。
DOI：
--
发表时间：
1980
期刊：
影响因子：
--
作者：
B. Weir;P. Avery;W. G. Hill
通讯作者：
W. G. Hill
近亲繁殖理论
DOI：
--
发表时间：
1949
期刊：
影响因子：
--
作者：
R. Fisher
通讯作者：
R. Fisher
影响因子：
4.9
作者：
Sanderson JL;Wang J;Vitikainen EI;Cant MA;Nichols HJ
通讯作者：
Nichols HJ
脊椎动物合作繁殖中近交避免和容忍的原因和后果
影响因子：
2
作者：
H. Nichols
通讯作者：
H. Nichols