HEPATOTOXIC AND NEPHROTOXIC PRINCIPLES IN TERMINALIA-OBLONGATA
HEPATOTOXIC AND NEPHROTOXIC PRINCIPLES IN TERMINALIA-OBLONGATA
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DOI：
10.1016/0034-5288(91)90101-s
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发表时间：
1991-03-01
影响因子：
2.4
通讯作者：
ENGLISH, PB
中科院分区：
文献类型：
--
作者：
FILIPPICH, LJ;ZHU, J;ENGLISH, PB
进行了一项研究来鉴定和表征长圆榄仁（俗称黄木）的毒性原理。 黄木叶的粗水提取物被发现在小鼠体内产生与反刍动物相同的肝脏损伤。 分离出肝毒性部分并鉴定为一种可水解植物单宁，称为安石榴苷。 口服给药时，产生毒性所需的剂量至少是腹膜内给药时的20倍。 在给定剂量的安石榴苷后，发现肝坏死的发生和严重程度与给药后的时间间隔有关。 除安石榴甙外，还发现了一种不明的肾毒性物质，能够产生肾缺血性坏死，但不引起肝坏死。
A study was conducted to identify and characterise the toxic principle in Terminalia oblongata, commonly known as yellow-wood. Crude aqueous extracts of yellow-wood leaf were found to produce the same liver lesion in mice as has been reported in ruminants. The hepatotoxic fraction was isolated and identified as a hydrolysable vegetable tannin called punicalagin. When given orally, the dose required to produce toxicity was at least 20 times greater than when given intraperitoneally. Following a given dose of punicalagin, the onset and severity of liver necrosis was found to be related to the time interval after dosing. In addition to punicalagin, and unidentified nephrotoxic substance was found which was capable of producing avascular renal necrosis without liver necrosis.