Pharmacological perspective: glycyrrhizin may be an efficacious therapeutic agent for COVID-19
Pharmacological perspective: glycyrrhizin may be an efficacious therapeutic agent for COVID-19
复制标题
DOI：
10.1016/j.ijantimicag.2020.105995
复制
发表时间：
2020-06-01
影响因子：
10.8
通讯作者：
Li, Juan
中科院分区：
文献类型：
--
作者：
Luo, Pan;Liu, Dong;Li, Juan
2019年冠状病毒病（COVID-19）由以前未知的病原体严重急性呼吸综合征相关冠状病毒2（SARS-CoV-2）引起，现已成为全球大流行病。目前还没有针对这种新病毒的疫苗或特异性治疗方法;因此，迫切需要推进新型COVID-19的治疗干预措施。甘草皂苷是一种具有多种生物学功能和药理作用的三萜皂苷。这篇简要的文章从其药理作用的角度讨论了Epharin治疗COVID-19的治疗潜力，包括结合血管紧张素转换酶II（ACE 2），下调促炎细胞因子，抑制细胞内活性氧（ROS）的积累，抑制凝血酶，抑制气道渗出物的过度产生，以及诱导内源性干扰素。(C)2020 Elsevier B. V.和国际化疗学会。All rights reserved.
Coronavirus disease 2019 (COVID-19) caused by the previously unknown pathogen, severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) is now a global pandemic. There are no vaccines or specific treatments against this new virus; therefore, there is an urgent need to advance novel therapeutic interventions for COVID-19. Glycyrrhizin is a triterpene saponin with various biological functions and pharmacological effects. This brief article discusses the therapeutic potential of glycyrrhizin for the treatment of COVID-19 from the perspective of its pharmacological action, including binding angiotensinconverting enzyme II (ACE2), downregulating proinflammatory cytokines, inhibiting the accumulation of intracellular reactive oxygen species (ROS), inhibiting thrombin, inhibiting the hyperproduction of airway exudates, and inducing endogenous interferon. (C) 2020 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.