Effect of masseter muscle mass on the rate of experimental tooth movement in rats
Effect of masseter muscle mass on the rate of experimental tooth movement in rats
复制标题
咬肌质量对大鼠实验性牙齿移动率的影响
DOI：
10.1111/joor.13357
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发表时间：
2022
影响因子：
2.9
通讯作者：
Noriaki Yoshida
中科院分区：
文献类型：
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作者：
Keira Arizono-Shimada;Hitoshi Hotokezaka;Yukiko Morita;Airi Ino-Kondo;Yuika Ueda-Ichinose;Yukako Nashiro;Yuka Hotokezaka;Keiko Yoshimi;Stavros Kiliaridis;Noriaki Yoshida
背景以往的临床观察研究表明，正畸牙齿移动（OTM）至少部分相关，本研究旨在通过A型肉毒杆菌神经毒素（botulinum neurotoxin type A，BTX）对咀嚼肌进行调节的动物实验模型，研究咀嚼肌质量对OTM的影响。方法将18只Wistar大鼠平均分为两组：BTX注射组和对照组。将BTX双侧注射到咬肌中。注射后3天，上颌左第一磨牙移动14天。在实验结束时，进行微型计算机断层扫描以评价OTM和骨形态测量的比率。咬肌称重，并准备用于histological analysis.ResultsThe咬肌质量在BTX组小于在对照组，和组织学检查结果显示肌纤维萎缩。BTX组OTM发生率显著高于对照组。此外，在BTX组中，咬肌质量与OTM之间呈负相关。骨形态测量显示，控制和BTX groups.ConclusionDecreased咬肌质量之间没有差异被发现是密切相关的，在大鼠使用BTX注射修改咬肌质量的OTM率的增加。咬肌质量可以作为BTX大鼠OTM的预测因子。
BackgroundPrevious clinical observational studies have suggested that orthodontic tooth movement (OTM) is related, at least partly, to the mass and/or capabilities of the masticatory muscles.ObjectivesOur study aimed to examine the influence of masticatory muscle mass on the OTM in an animal experimental model in which the masseter muscle was modulated by botulinum neurotoxin type A (BTX) injection.MethodsEighteen Wistar rats were equally divided into two groups: BTX injection and control. BTX was injected bilaterally into the masseter muscles. Three days after the injection, the maxillary left first molars were orthodontically moved for 14 days. At the end of the experiment, micro‐computed tomography was performed to evaluate the rate of OTM and bone morphometry. The masseter muscles were weighed and prepared for histological analyses.ResultsThe masseter muscle mass in the BTX group was less than that in the control group, and histological findings showed atrophy of muscle fibres. The rate of OTM was significantly higher in the BTX group than in the control group. Furthermore, a negative correlation was detected between masseter muscle mass and OTM in the BTX group. Bone morphometry showed no difference between the control and BTX groups.ConclusionDecreased masseter muscle mass was found to be closely related to an increase in the rate of OTM in rats using BTX injection to modify the masseter muscle mass. Masseter muscle mass could be a predictive factor for OTM in rats injected with BTX.