Different Ca2+ source for slow AHP in completely adapting and repetitive firing pyramidal neurons.
Different Ca2+ source for slow AHP in completely adapting and repetitive firing pyramidal neurons.
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DOI：
10.1097/00001756-199906230-00029
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发表时间：
1999-06
期刊：
影响因子：
1.7
通讯作者：
J. C. Pineda;E. Galarraga;R. Foehring
中科院分区：
文献类型：
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作者：
J. C. Pineda;E. Galarraga;R. Foehring
利用幼年大鼠新皮质脑片的细胞内记录，研究了锥体神经元慢后超极化(SAHP)产生的钙来源。在长时间保持重复放电的锥体神经元(RF神经元)中，N-、P-和Q型钙通道为SAHP的产生提供钙。在CA神经元上，这些钙通道类型的拮抗剂和L类通道的拮抗剂联合使用，仅使SAHP降低50%。阻断钙离子释放的兰尼定和丹曲林可使CA神经元的SAHP降低约45%，但对RF神经元的SAHP无明显影响。丹曲林可使CA神经元在1s的阈值以上电流注射过程中产生放电(RF神经元也是如此)。
Intracellular recordings in an in vitro neocortical slice preparation from immature rats were used to investigate the Ca2 source for slow afterhyperpolarization (sAHP) generation in pyramidal neurons that exhibit complete spike frequency adaptation (CA neurons). In pyramidal neurons that maintain repetitive firing for long periods of time (RF neurons), N-, P- and Q-type Ca2+ channels supply Ca2+ for sAHP generation. In CA neurons, the sAHP was reduced by only 50% by the combination of antagonists for these Ca2+ channel types and L-type channels. Ryanodine and dantrolene, blockers of Ca2(+)-induced Ca2+ release, reduced the sAHP by approximately 45% in CA neurons, but caused no reduction of the sAHP in RF neurons. Dantrolene application caused CA neurons to fire throughout a 1s suprathreshold current injection (as do RF neurons).