γ-Lactam alkaloids from the flower buds of daylily
γ-Lactam alkaloids from the flower buds of daylily
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DOI：
10.1007/s11418-015-0963-z
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发表时间：
2016-07-01
影响因子：
3.3
通讯作者：
Matsuda, Hisashi
中科院分区：
文献类型：
--
作者：
Matsumoto, Takahiro;Nakamura, Seikou;Matsuda, Hisashi
从黄花菜花蕾的甲醇提取物中分离得到4个新生物碱，命名为萱草胺Ⅳ-Ⅶ。根据化学和物理化学证据阐明了新化合物的化学结构。通过应用改进的Mosher方法、HPLC分析和旋光度，阐明了大花香蒜胺IV-VI的绝对立体化学。在本研究中，分离的生物碱在体外显著抑制A β 42的聚集。这是首次从黄花菜中分离得到具有γ-内酰胺环结构的生物活性生物碱。此外，在非禁食条件下，分离核苷对神经突起生长有促进作用。
Four new alkaloids, hemerocallisamines IV-VII, were isolated from the methanol extract of flower buds of daylily. The chemical structures of the new compounds were elucidated on the basis of chemical and physicochemical evidence. The absolute stereochemistry of the hemerocallisamines IV-VI was elucidated by the application of the modified Mosher's method, HPLC analysis, and optical rotation. In the present study, the isolated alkaloids significantly inhibited the aggregation of A beta 42 in vitro. This is the first report about bioactive alkaloids with a gamma-lactam ring from daylily. In addition, isolated nucleosides showed accelerative effects on neurite outgrowth under the non-fasting condition.