Conversion of Polyethylenes into Fungal Secondary Metabolites.
Conversion of Polyethylenes into Fungal Secondary Metabolites.
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DOI：
10.1002/anie.202214609
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发表时间：
2023-01-23
影响因子：
16.6
通讯作者：
Wang, Clay C. C.
中科院分区：
文献类型：
--
作者：
Rabot, Chris;Chen, Yuhao;Bijlani, Swati;Chiang, Yi-Ming;Oakley, C. Elizabeth;Oakley, Berl R.;Williams, Travis J.;Wang, Clay C. C.
废塑料是主要的环境和经济负担，因为它们无处不在，分解速度慢，目前的回收途径不足。聚乙烯尤其成问题，因为它们缺乏强有力的回收方法，尽管它们是当今使用的最丰富的塑料。我们报道了一种新的化学和生物学方法，用于将聚乙烯快速转化为结构复杂和具有生物活性的化合物。我们提出了从消费后和海洋废物流中收集的聚乙烯的好氧催化消化条件，产生羧酸，然后可以被真菌构巢曲霉用作碳源。作为原理的证明，我们已经改造了A.当在这些消化产物上生长时，nidulans能够合成真菌次级代谢物曲霉苯甲醛、黄绿青霉素和木替林。这种混合方法大大扩展了聚乙烯可以升级循环的产品范围。从加利福尼亚州卡塔利纳岛的卡塔利纳港收集混合塑料。在分选之后，聚乙烯被催化降解成羧酸。这些二酸然后通过构巢曲霉的工程菌株升级为结构多样的次级代谢产物。相差显微照片显示在含有聚乙烯消化物的液体培养基中有大量的阿斯平苯甲醛晶体。
Waste plastics represent major environmental and economic burdens due to their ubiquity, slow breakdown rates, and inadequacy of current recycling routes. Polyethylenes are particularly problematic, because they lack robust recycling approaches despite being the most abundant plastics in use today. We report a novel chemical and biological approach for the rapid conversion of polyethylenes into structurally complex and pharmacologically active compounds. We present conditions for aerobic, catalytic digestion of polyethylenes collected from post‐consumer and oceanic waste streams, creating carboxylic diacids that can then be used as a carbon source by the fungus Aspergillus nidulans. As a proof of principle, we have engineered strains of A. nidulans to synthesize the fungal secondary metabolites asperbenzaldehyde, citreoviridin, and mutilin when grown on these digestion products. This hybrid approach considerably expands the range of products to which polyethylenes can be upcycled. Mixed plastics were collected from Catalina Harbor on Catalina Island, CA. After sorting, polyethylenes were catalytically degraded into carboxylic diacids. These diacids are then upgraded by engineered strains of Aspergillus nidulans into structurally diverse secondary metabolites. Phase contrast micrographs show ample asperbenzaldehyde crystals in liquid culture medium containing polyethylene digest.
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影响因子：
13.6
作者：
Geyer R;Jambeck JR;Law KL
通讯作者：
Law KL
在温和条件下将聚乙烯高效选择性降解为液体燃料和蜡
影响因子：
13.6
作者：
Jia X;Qin C;Friedberger T;Guan Z;Huang Z
通讯作者：
Huang Z
影响因子：
3.5
作者：
Li A;Pfelzer N;Zuijderwijk R;Punt P
通讯作者：
Punt P
影响因子：
4.2
作者：
Backstrom, Eva;Odelius, Karin;Hakkarainen, Minna
通讯作者：
Hakkarainen, Minna
DOI：
10.1073/pnas.1410657111
发表时间：
2014-08-19
影响因子：
11.1
作者：
Linger, Jeffrey G.;Vardon, Derek R.;Beckham, Gregg T.
通讯作者：
Beckham, Gregg T.