Genetic variants, pathophysiological pathways, and oral anticoagulation in patients with hypertrophic cardiomyopathy and atrial fibrillation.
Genetic variants, pathophysiological pathways, and oral anticoagulation in patients with hypertrophic cardiomyopathy and atrial fibrillation.
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DOI：
10.3389/fcvm.2023.1023394
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发表时间：
2023
影响因子：
3.6
通讯作者：
He, Wenfeng
中科院分区：
文献类型：
--
作者：
Wang, Shengnan;Chen, He;Liu, Chunju;Wu, Mengxian;Sun, Wanlei;Liu, Shenjian;Zheng, Yan;He, Wenfeng
心房颤动（AF）在肥厚型心肌病（HCM）患者中普遍存在。然而，基因型阳性与基因型阴性的HCM患者之间AF的患病率和发生率是否存在差异仍存在争议。最近的证据表明，AF往往是第一个介绍的遗传HCM患者在没有心肌病表型，这意味着在这个人口中的遗传检测的重要性早发性AF。然而，协会的肌节基因变异与HCM的发生在未来仍然不清楚。这些心肌病基因变异的鉴定如何影响早发性房颤患者的抗凝治疗仍不明确。在这篇综述中，我们试图评估HCM和AF患者的遗传变异、病理生理学途径和口服抗凝药物。
Atrial fibrillation (AF) is commonly prevalent in patients with hypertrophic cardiomyopathy (HCM). However, whether the prevalence and incidence of AF are different between genotype-positive vs. genotype-negative patients with HCM remains controversial. Recent evidence has indicated that AF is often the first presentation of genetic HCM patients in the absence of a cardiomyopathy phenotype, implying the importance of genetic testing in this population with early-onset AF. However, the association of the identified sarcomere gene variants with HCM occurrence in the future remains unclear. How the identification of these cardiomyopathy gene variants should influence the use of anticoagulation therapy for a patient with early-onset AF is still undefined. In this review, we sought to assess the genetic variants, pathophysiological pathways, and oral anticoagulation in patients with HCM and AF.
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影响因子：
1.5
作者：
Lin，Yunchai;Xiong，Hongping;Peng，Feng
通讯作者：
Peng，Feng
肉瘤蛋白滴定中的罕见截断变体与家族性和早期心房颤动相关。
影响因子：
16.6
作者：
Ahlberg G;Refsgaard L;Lundegaard PR;Andreasen L;Ranthe MF;Linscheid N;Nielsen JB;Melbye M;Haunsø S;Sajadieh A;Camp L;Olesen SP;Rasmussen S;Lundby A;Ellinor PT;Holst AG;Svendsen JH;Olesen MS
通讯作者：
Olesen MS
影响因子：
9.7
作者：
Lee, Seung-Pyo;Ashley, Euan A.;Perez, Marco V.
通讯作者：
Perez, Marco V.
影响因子：
1.8
作者：
Brito, Dulce;Miltenberger-Miltenyi, Gabriel;Madeira, Hugo
通讯作者：
Madeira, Hugo
影响因子：
20.1
作者：
Laws, J. Lukas;Lancaster, Megan C.;Ben Shoemaker, M.;Stevenson, William G.;Hung, Rebecca R.;Wells, Quinn;Brinkley, D. Marshall;Hughes, Sean;Anderson, Katherine;Roden, Dan;Stevenson, Lynne W.
通讯作者：
Stevenson, Lynne W.