Global Methylation in the Placenta and Umbilical Cord Blood From Pregnancies With Maternal Gestational Diabetes, Preeclampsia, and Obesity
Global Methylation in the Placenta and Umbilical Cord Blood From Pregnancies With Maternal Gestational Diabetes, Preeclampsia, and Obesity
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DOI：
10.1177/1933719113492206
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发表时间：
2014-01-01
影响因子：
2.9
通讯作者：
Chen, Jia
中科院分区：
文献类型：
--
作者：
Nomura, Yoko;Lambertini, Luca;Chen, Jia
新出现的证据表明，母亲在怀孕期间的医疗风险，如妊娠糖尿病（GDM），先兆子痫和肥胖，易使后代发育不良。然而，子宫内潜在的生物学/表观遗传机制仍然未知。目前的初步研究（N = 50）比较了患有和不患有每种风险状况（GDM，先兆子痫和肥胖）的女性胎盘和脐带血中的整体甲基化水平，并探讨了整体甲基化水平是否与胎儿/婴儿生长相关。结果显示，妊娠期糖尿病（P = 0.003）和先兆子痫（P = 0.05）患者胎盘中的整体甲基化水平较低，但肥胖患者较高（P = 0.01）。胎盘中的甲基化水平与婴儿的身长和头围呈负相关。虽然是初步的，但胎盘组织（而不是脐带血）可能通过母体GDM、先兆子痫和肥胖进行表观遗传编程，以执行其自身影响胎儿生长的特定功能。
Emerging evidence indicates that maternal medical risk during pregnancy, such as gestational diabetes mellitus (GDM), preeclampsia, and obesity, predisposes the offspring to suboptimal development. However, the underlying biological/epigenetic mechanism in utero is still unknown. The current pilot study (N = 50) compared the levels of global methylation in the placenta and umbilical cord blood among women with and without each risk condition (GDM, preeclampsia, and obesity) and explored whether the levels of global methylation were associated with fetal/infant growth. Results show that global methylation levels in the placenta were lower in patients with gestational diabetes (P = .003) and preeclampsia (P = .05) but higher with obesity (P = .01). Suggestive negative associations were found between global methylation level in the placenta and infant body length and head circumference. While preliminary, it is possible that the placenta tissue, but not umbilical cord blood, may be epigenetically programmed by maternal GDM, preeclampsia, and obesity to carry out its own specific functions that influence fetal growth.