Apatite Coating on Organic Polymers by a Biomimetic Process
Apatite Coating on Organic Polymers by a Biomimetic Process
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通过仿生工艺在有机聚合物上涂覆磷灰石
DOI：
10.1111/j.1151-2916.1994.tb04508.x
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发表时间：
1994
影响因子：
3.9
通讯作者：
T. Yamamuro
中科院分区：
文献类型：
--
作者：
M. Tanahashi;T. Yao;T. Kokubo;M. Minoda;T. Miyamoto;Takashi Nakamura;T. Yamamuro
可以通过以下仿生方法在各种有机聚合物上形成致密且均匀的含生物活性碳酸盐的羟基磷灰石层。首先，将基板与浸泡在模拟体液（SBF）中的 CaO-SiO2 基玻璃颗粒接触，离子浓度几乎等于人体血浆的离子浓度，以在基板上形成磷灰石核。其次，将基材浸泡在另一种对磷灰石高度过饱和的溶液中，例如离子浓度为SBF的1.5倍(1.5SBF)，以使磷灰石核在基材上原位生长。磷灰石成核的诱导期（定义为在第二次处理后形成足够的磷灰石核以形成连续层所需的第一次处理的时间）对于大多数所检查的聚合物而言几乎为 24 小时。对于聚对苯二甲酸乙二醇酯、聚醚砜和聚(乙烯醇)水凝胶，所形成的磷灰石层与聚合物的粘合强度高达3至4MPa。这种类型的磷灰石-有机聚合物复合材料预计不仅可用于修复活体硬组织，而且还可用于修复软组织。
Dense and uniform layers of a biologically active carbonate-containing hydroxyapatite can be formed on various kinds of organic polymers by the following biomimetic method. First, a substrate is set in contact with particles of CaO–SiO2-based glass soaked in a simulated body fluid (SBF) with ion concentrations nearly equal to those of human blood plasma for forming the apatite nuclei on the substrate. Second, the substrate is soaked in another solution highly supersaturated with respect to the apatite, e.g, with ion concentrations 1.5 times those of SBF (1.5SBF) for making the apatite nuclei grow on the substrate in situ. The induction period for the apatite nucleation, which is defined as the time of the first treatment required for forming enough of the apatite nuclei to make the continuous layer after the second treatment, was almost 24 h for most of the examined polymers. The adhesive strength of the formed apatite layer to the polymers was as high as 3 to 4 M Pa for poly(ethylene terephthalate), poly-ether sulfone, and poly (vinyl alcohol) hydrogel. This type of apatite–organic polymer composite is expected to be useful for repairing not only living hard tissues but also soft ones.